Influence of changes in pretransplant sensitization on patient and graft survival in cadaver renal transplantation

Fred Sanfilippo, W. K. Vaughn, E. K. Spees, R. R. Bollinger

Research output: Contribution to journalArticle

Abstract

Analysis of 2778 primary and 606 regrafted cadaveric donor renal allograft recipients transplanted between June 1977 and July 1982 as part of the South-Eastern Organ Procurement Foundation (SEOPF) Prospective Study was performed to determine the influence ofchanges in presensitization on graft and patient outcome. Four mutually exclusive groups of patients were identified based on the relative difference in the percentage of panel-reactive antibody (PRA) from highest ever (peak) to most recent (current) pretransplant levels as follows: group 1 (unsensitized): peak = current PRA = 0; group 2 (rising or stable PRA): (peak = current PRA) >0; group 3 (small decrease): (peak - current PRA) = 1–40%) and group 4 (large decrease): (peak - current PRA)>40%. First-transplant recipients in group 4 had significantly higher mortality when comparedwith groups 1–3 (P40% had significantly lower overall graft survival (P

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalTransplantation
Volume38
Issue number2
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Sanfilippo, F., Vaughn, W. K., Spees, E. K., & Bollinger, R. R. (1984). Influence of changes in pretransplant sensitization on patient and graft survival in cadaver renal transplantation. Transplantation, 38(2), 124-129.