Influence of Bioreceptor Layer Structure on Myelin Basic Protein Detection using Organic Field Effect Transistor-Based Biosensors

Jian Song, Jennifer Dailey, Hui Li, Hyun June Jang, Luisa Russell, Pengfei Zhang, Peter C. Searson, Jeff Tza Huei Wang, Allen D Everett, Howard E. Katz

Research output: Contribution to journalArticlepeer-review

Abstract

Organic field-effect transistor (OFET)-based biosensors with antibody receptors are widely considered for protein antigen detection. To the authors' knowledge, there are no comparative evaluations to date of different choices for the matrix polymer to which the antibodies are attached. Herein, multiple acrylic copolymers are studied as receptor layers with myelin basic protein and its corresponding antibody as an archetypal antibody-antigen pair. Stability against multiple washing steps and the capacity for immobilizing antibodies on polymers on device surfaces with the help of fluorescein isothiocyanate-labeled antibodies are compared. Electronic detection and selectivity are also observed. The conclusions provide guidance on the selection of bioreceptor material for increasing sensitivity and process stability of OFET biosensors.

Original languageEnglish (US)
JournalAdvanced Functional Materials
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Acrylic copolymers
  • Bioreceptor layers
  • Biosensors
  • Myelin basic protein detection
  • OFETs

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

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