Influência do treinamento físico aeróbio no transporte mitocondrial de ácidos graxos de cadeia longa no músculo esquelético: Papel do complexo carnitina palmitoil transferase

Translated title of the contribution: Influence of aerobic physical training in the motochondrial transport of long chain fatty acids in the skeletal muscle: Role of the carnitine palmitoil transferase

Alex Shimura Yamashita, Fábio Santos Lira, Waldecir Paula Lima, Luiz Carlos Carnevali, Daniela Caetano Gonçalves, Fábio Luis Tavares, Marília Cerqueira Leite Seelaender

Research output: Contribution to journalReview articlepeer-review

Abstract

Fatty acids are an important source of energy for the skeletal muscle. During exercise, their mobilization is increased to supply the muscle energetic needs. Many points of regulation act in the fatty acids metabolism, where the carnitine palmytoiltransferase (CPT) complex is the main control system. Three compounds named CPT I, CPT II and carnitine acyl carnitine translocase (CACT) are components of this system. Its function is to control the influx of fatty acids inside the mitochondria for posterior oxidation and energy production. There is a pronounced increase in both activity and gene expression of CPT I in the skeletal muscle in response to exercise. Due to its importance in lipid metabolism, the controlling mechanisms are reviewed in the present study. The modulation of gene expression by peroxisome proliferator-activated receptors (PPARs) alpha and beta during the physical training is also discussed in this review.

Translated title of the contributionInfluence of aerobic physical training in the motochondrial transport of long chain fatty acids in the skeletal muscle: Role of the carnitine palmitoil transferase
Original languagePortuguese
Pages (from-to)150-154
Number of pages5
JournalRevista Brasileira de Medicina do Esporte
Volume14
Issue number2
DOIs
StatePublished - 2008
Externally publishedYes

Keywords

  • Gene expression
  • Lipid metabolism
  • Long chain fatty acid transport
  • Peroxisome proliferator activated receptors

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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