Inflation-fixed lungs: Pathologic-radiologic (CT) correlation of lung transplantation

Ralph H. Hruban, Hua Ren, Janet E. Kuhlman, Elliot K. Fishman, Paul S. Wheeler, William A. Baumgartner, Bruce A. Reitz, Grover M. Hutchins

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Pulmonary infections and lung rejection are the two major complications of lung transplantation. Although the therapies for these two processes differ greatly, they often cannot be differentiated using standard radiography. We applied high resolution CT (HRCT) to seven lung specimens that were obtained from patients who had received a heart-lung transplant. The lungs were fixed by a method that allows for direct one-to-one pathologic-radiologic correlation. We found: (a) that in contrast to the extensive changes present microscopically, acute lung allograft rejection was characterized by only minor changes on HRCT; (b) that bronchiolitis obliterans, the hallmark of chronic lung allograft rejection, was not reliably identifiable on HRCT; (c) that bronchiectasis with associated peribronchial inflammation and fibrosis, a common finding in lung allograft rejection, was identifiable on HRCT, but that the HRCT appearance of this lesion was not specific for rejection; and (d) that pulmonary infections were often identifiable as a mixed airway-interstitial process on HRCT.

Original languageEnglish (US)
Pages (from-to)329-335
Number of pages7
JournalJournal of computer assisted tomography
Issue number3
StatePublished - May 1990


  • Computed tomography
  • Diseases
  • Lungs
  • Techniques
  • Transplants and transplantations

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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