Abstract
Inflammatory responses occur rapidly after intracerebral hemorrhage and participate in both short-term toxicity and long-term recovery. Microglia/macrophages react to hemorrhagic injury and exhibit dynamic phenotypes and phagocytic capability. Astrocytes secrete cytokines, chemokines, and gliotransmitters that can regulate neuroinflammation. In addition, infiltrating neutrophils and T-lymphocytes modulate immunoreactions, which further cross-talk with microglia/macrophages. Thus, the search for effective immunotherapy to target specific cell type-mediated inflammation might represent a new direction for intracerebral hemorrhage treatment, separate from traditional anti-inflammatory drug discovery.
Original language | English (US) |
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Pages (from-to) | 184-186 |
Number of pages | 3 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 39 |
Issue number | 1 |
DOIs |
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State | Published - Jan 1 2019 |
Keywords
- Astrocytes
- intracerebral hemorrhage
- microglia
- neuroinflammation
- phagocytosis
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine