Inflammatory responses after intracerebral hemorrhage: From cellular function to therapeutic targets

Xi Lan, Xiaoning Han, Xi Liu, Jian Wang

Research output: Contribution to journalComment/debate

Abstract

Inflammatory responses occur rapidly after intracerebral hemorrhage and participate in both short-term toxicity and long-term recovery. Microglia/macrophages react to hemorrhagic injury and exhibit dynamic phenotypes and phagocytic capability. Astrocytes secrete cytokines, chemokines, and gliotransmitters that can regulate neuroinflammation. In addition, infiltrating neutrophils and T-lymphocytes modulate immunoreactions, which further cross-talk with microglia/macrophages. Thus, the search for effective immunotherapy to target specific cell type-mediated inflammation might represent a new direction for intracerebral hemorrhage treatment, separate from traditional anti-inflammatory drug discovery.

Original languageEnglish (US)
Pages (from-to)184-186
Number of pages3
JournalJournal of Cerebral Blood Flow and Metabolism
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Astrocytes
  • intracerebral hemorrhage
  • microglia
  • neuroinflammation
  • phagocytosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Inflammatory responses after intracerebral hemorrhage: From cellular function to therapeutic targets'. Together they form a unique fingerprint.

  • Cite this