Inflammatory pseudotumors of the major salivary glands: Clinicopathologic and immunohistochemical analysis of six cases

S. B. Williams, R. D. Foss, G. L. Ellis

Research output: Contribution to journalArticle

Abstract

Inflammatory pseudotumor is a pathologic term used to describe reactive, pseudoneoplastic phenomena, which reportedly occur in many parts of the body. Clinicopathologic and immunohistochemical findings in six cases of inflammatory pseudotumor of the major salivary glands are described. All six lesions involved the parotid gland. There were three men and three women affected, with a median age of 72.5 years. All patients presented with a swelling of several months' duration in the parotid region. Five patients were alive and free of tumor at an average of 3.2 years after surgical removal, and one patient was lost to follow-up. The lesions were firm, discrete nodules, grossly described as homogenous yellow-gray tissue. Histologically, all lesions contained a diversified admixture of four histological elements: (a) myofibroblasts, (b) histiocytes, (c) plasma cells, and (d) lymphocytes. Results of immunohistochemical studies showed a biphasic spindle cell population of myofibroblasts and histiocytes with variable staining characteristics for KP-1(CD-3), smooth muscle actin, muscle-specific actin, and vimentin. These findings are in agreement with the concept that inflammatory pseudotumor is a fibroinflammatory lesion with an abundant component of myofibroblastic/fibrohistiocytic elements.

Original languageEnglish (US)
Pages (from-to)896-902
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume16
Issue number9
StatePublished - 1992
Externally publishedYes

Fingerprint

Plasma Cell Granuloma
Salivary Glands
Histiocytes
Myofibroblasts
Actins
Parotid Region
Lost to Follow-Up
Parotid Gland
Vimentin
Plasma Cells
Human Body
Smooth Muscle
Lymphocytes
Staining and Labeling
Muscles
Population
Neoplasms

Keywords

  • Inflammatory pseudotumor
  • Parotid gland

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Inflammatory pseudotumors of the major salivary glands : Clinicopathologic and immunohistochemical analysis of six cases. / Williams, S. B.; Foss, R. D.; Ellis, G. L.

In: American Journal of Surgical Pathology, Vol. 16, No. 9, 1992, p. 896-902.

Research output: Contribution to journalArticle

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