Inflammatory myopathies

Ira N. Targoff, Chester V. Oddis, Paul H. Plotz, Frederick W. Miller, Mark Gourley

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disorders characterized by varied patterns of inflammation within striated muscle. The major disease categories among the IIM are der-matomyositis (DM), polymyositis (PM), inclusion body myositis (IBM), myositis associated with connective tissue diseases, and myositis associated with malignancy. The skin, joints, lungs, heart, and gastrointestinal tract are also involved in different forms of these disorders. Muscle weakness that is proximal, symmetrical, and painless is a hallmark feature of the inflammatory myopathies. Patients with IBM are also prone to distal, asymmetric muscle involvement. Measurement of serum concentrations of muscle enzymes, skin and muscle biopsy, electromyography, and magnetic resonance imaging can assist in the diagnosis. Testing for serum autoantibodies is helpful both in diagnosis and in predicting the clinical phenotype and response to therapy. A minority of patients with DM and PM have myositis that is associated with an underlying malignancy. The risk is greatest for middle-aged to elderly patients with DM. Approximately 15% of DM patients have malignancy-associated disease. Most malignancies present within 1 year before or after the diagnosis of inflammatory myopathy.

Original languageEnglish (US)
Title of host publicationA Clinician's Pearls and Myths in Rheumatology
PublisherSpringer London
Pages191-199
Number of pages9
ISBN (Print)9781848009332
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Myositis
Inclusion Body Myositis
Polymyositis
Muscles
Neoplasms
Skin
Connective Tissue Diseases
Striated Muscle
Muscle Weakness
Electromyography
Serum
Autoantibodies
Gastrointestinal Tract
Joints
Magnetic Resonance Imaging
Inflammation
Phenotype
Biopsy
Lung
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Targoff, I. N., Oddis, C. V., Plotz, P. H., Miller, F. W., & Gourley, M. (2009). Inflammatory myopathies. In A Clinician's Pearls and Myths in Rheumatology (pp. 191-199). Springer London. https://doi.org/10.1007/978-1-84800-934-9_18

Inflammatory myopathies. / Targoff, Ira N.; Oddis, Chester V.; Plotz, Paul H.; Miller, Frederick W.; Gourley, Mark.

A Clinician's Pearls and Myths in Rheumatology. Springer London, 2009. p. 191-199.

Research output: Chapter in Book/Report/Conference proceedingChapter

Targoff, IN, Oddis, CV, Plotz, PH, Miller, FW & Gourley, M 2009, Inflammatory myopathies. in A Clinician's Pearls and Myths in Rheumatology. Springer London, pp. 191-199. https://doi.org/10.1007/978-1-84800-934-9_18
Targoff IN, Oddis CV, Plotz PH, Miller FW, Gourley M. Inflammatory myopathies. In A Clinician's Pearls and Myths in Rheumatology. Springer London. 2009. p. 191-199 https://doi.org/10.1007/978-1-84800-934-9_18
Targoff, Ira N. ; Oddis, Chester V. ; Plotz, Paul H. ; Miller, Frederick W. ; Gourley, Mark. / Inflammatory myopathies. A Clinician's Pearls and Myths in Rheumatology. Springer London, 2009. pp. 191-199
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