Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: An unusual presentation of an unusual neoplasm

Anya N A Milne, Karl J. Sweeney, Diarmuid S. O'Riordain, Patrick Pauwels, Maria Debiec-Rychter, G. Johan A Offerhaus, Michael Jeffers

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalHuman Pathology
Volume37
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Keywords

  • Anaplastic lymphoma kinase
  • Inflammatory myofibroblastic tumor
  • Intussusception

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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