Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: An unusual presentation of an unusual neoplasm

Anya N A Milne; Karl J. Sweeney; Diarmuid S. O'Riordain; Patrick Pauwels; Maria Debiec-Rychter; G. Johan A Offerhaus; Michael Jeffers

doi:10.1016/j.humpath.2005.09.012

Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: An unusual presentation of an unusual neoplasm

Anya N A Milne, Karl J. Sweeney, Diarmuid S. O'Riordain, Patrick Pauwels, Maria Debiec-Rychter, G. Johan A Offerhaus, Michael Jeffers

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.

Original language	English (US)
Pages (from-to)	112-116
Number of pages	5
Journal	Human Pathology
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.humpath.2005.09.012
State	Published - Jan 2006
Externally published	Yes

Keywords

Anaplastic lymphoma kinase
Inflammatory myofibroblastic tumor
Intussusception

ASJC Scopus subject areas

Pathology and Forensic Medicine

Access to Document

10.1016/j.humpath.2005.09.012

Cite this

@article{2dc91b9f88984e72bb1c55551972fb14,

title = "Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: An unusual presentation of an unusual neoplasm",

abstract = "Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.",

keywords = "Anaplastic lymphoma kinase, Inflammatory myofibroblastic tumor, Intussusception",

author = "Milne, {Anya N A} and Sweeney, {Karl J.} and O'Riordain, {Diarmuid S.} and Patrick Pauwels and Maria Debiec-Rychter and Offerhaus, {G. Johan A} and Michael Jeffers",

year = "2006",

month = jan,

doi = "10.1016/j.humpath.2005.09.012",

language = "English (US)",

volume = "37",

pages = "112--116",

journal = "Human Pathology",

issn = "0046-8177",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception

T2 - An unusual presentation of an unusual neoplasm

AU - Milne, Anya N A

AU - Sweeney, Karl J.

AU - O'Riordain, Diarmuid S.

AU - Pauwels, Patrick

AU - Debiec-Rychter, Maria

AU - Offerhaus, G. Johan A

AU - Jeffers, Michael

PY - 2006/1

Y1 - 2006/1

N2 - Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.

AB - Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.

KW - Anaplastic lymphoma kinase

KW - Inflammatory myofibroblastic tumor

KW - Intussusception

UR - http://www.scopus.com/inward/record.url?scp=29044441467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29044441467&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2005.09.012

DO - 10.1016/j.humpath.2005.09.012

M3 - Article

C2 - 16360423

AN - SCOPUS:29044441467

SN - 0046-8177

VL - 37

SP - 112

EP - 116

JO - Human Pathology

JF - Human Pathology

IS - 1

ER -

Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: An unusual presentation of an unusual neoplasm

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this