Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia

Faith Dickerson, Cassie Stallings, Andrea Origoni, Jennifer Schroeder, Emily Katsafanas, Lucy Schweinfurth, Christina Savage, Sunil Khushalani, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Background. Immune markers have been associated with schizophrenia, but few studies have examined multiple markers in both recent onset and chronic schizophrenia patients. Methods. The sample of 588 individuals included 79 with recent onset psychosis, 249 with chronic schizophrenia, and 260 controls. A combined inflammation score was calculated by principal components factor analysis of the levels of C-reactive protein, Pentraxin 3, and IgG antibodies to gliadin, casein, and Saccharomyces cerevisiae measured in blood samples. Inflammation scores among groups were compared by multivariate analyses. Results. The chronic schizophrenia group showed significant elevations in the combined inflammation score compared with controls. The recent onset group surprisingly showed a reduction in the combined inflammation score. Consistent with these findings, the chronic schizophrenia group had significantly increased odds of a combined inflammation score greater than the 75th and the 90th percentile of that of the controls. The recent onset group had significantly increased odds of a combined inflammation score less than the 10th and the 25th percentile level of the controls. Conclusions. The recent onset of psychosis may be associated with inherent deficits in innate immunity. Individuals later in the course of disease may have increased levels of innate immunity. The reasons for these changes are not known with certainty but may be related to compensatory increases as the disease progresses. Longitudinal studies are needed to determine the course of immune abnormalities in schizophrenia and their role in the clinical manifestations of the disorder.

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalSchizophrenia Bulletin
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2016

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Psychotic Disorders
Schizophrenia
Inflammation
Innate Immunity
Gliadin
Caseins
Principal Component Analysis
C-Reactive Protein
Statistical Factor Analysis
Longitudinal Studies
Saccharomyces cerevisiae
Multivariate Analysis
Immunoglobulin G
Biomarkers
Antibodies

Keywords

  • immunity
  • inflammation
  • psychosis
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Dickerson, F., Stallings, C., Origoni, A., Schroeder, J., Katsafanas, E., Schweinfurth, L., ... Yolken, R. H. (2016). Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia. Schizophrenia Bulletin, 42(1), 134-141. https://doi.org/10.1093/schbul/sbv108

Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia. / Dickerson, Faith; Stallings, Cassie; Origoni, Andrea; Schroeder, Jennifer; Katsafanas, Emily; Schweinfurth, Lucy; Savage, Christina; Khushalani, Sunil; Yolken, Robert H.

In: Schizophrenia Bulletin, Vol. 42, No. 1, 01.01.2016, p. 134-141.

Research output: Contribution to journalArticle

Dickerson, F, Stallings, C, Origoni, A, Schroeder, J, Katsafanas, E, Schweinfurth, L, Savage, C, Khushalani, S & Yolken, RH 2016, 'Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia', Schizophrenia Bulletin, vol. 42, no. 1, pp. 134-141. https://doi.org/10.1093/schbul/sbv108
Dickerson F, Stallings C, Origoni A, Schroeder J, Katsafanas E, Schweinfurth L et al. Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia. Schizophrenia Bulletin. 2016 Jan 1;42(1):134-141. https://doi.org/10.1093/schbul/sbv108
Dickerson, Faith ; Stallings, Cassie ; Origoni, Andrea ; Schroeder, Jennifer ; Katsafanas, Emily ; Schweinfurth, Lucy ; Savage, Christina ; Khushalani, Sunil ; Yolken, Robert H. / Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia. In: Schizophrenia Bulletin. 2016 ; Vol. 42, No. 1. pp. 134-141.
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