TY - JOUR
T1 - Inflammatory markers associated with subclinical coronary artery disease
T2 - The multicenter AIDS cohort study
AU - Bahrami, Hossein
AU - Budoff, Matthew
AU - Haberlen, Sabina A.
AU - Rezaeian, Pantea
AU - Ketlogetswe, Kerunne
AU - Tracy, Russell
AU - Palella, Frank
AU - Witt, Mallory D.
AU - McConnell, Michael V.
AU - Kingsley, Lawrence
AU - Post, Wendy S.
N1 - Funding Information:
The MACS CVD 2 study is funded by National Heart Lung and Blood Institute (NHLBI), RO1 HL095129 (Post), with additional support from UL1 RR 025005 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. The MACS is funded by the National Institute of Allergy and Infectious Diseases (NIAID), with additional supplemental funding from the National Cancer Institute (NCI), UO1-AI-35042, UL1-RR025005, UM1-AI-35043, UO1-AI-35039, UO1-AI-35040, UO1-AI-35041, and CTSI grant UL1TR000124. The leading and corresponding author (Bahrami) was supported in part by National Heart, Lung, and Blood Institute grant 5K23HL128164A and National Institute of Biomedical Imaging and Bioengineering (NIBIB) training grant to Stanford Cardiovascular Institute (5T32EB009035-06A1). The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official view of the NIH, NIAID, NCI, or NHLBI
Publisher Copyright:
© 2016 The Authors.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background-Despite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV- men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography. Methods and Results-Outcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin-6 (IL-6), intercellular adhesion molecule-1, C-reactive protein, and soluble-tumor necrosis factor-a receptor (sTNFαR) I and II (all P < 0.01) and a higher prevalence of noncalcified plaque (63% versus 54%, P=0.02) on computed tomography angiography. Among HIV+ men, for every SD increase in log-interleukin-6 and log intercellular adhesion molecule-1, there was a 30% and 60% increase, respectively, in the prevalence of coronary stenosis ≥50% (all P < 0.05). Similarly, sTNFαR I and II in HIV+ participants were associated with an increase in prevalence of coronary stenosis ≥70% (P < 0.05). Higher levels of interleukin-6, sTNFαR I, and sTNFαR II were also associated with greater coronary artery calcification score in HIV+ men (P < 0.01). Conclusions-Higher inflammatory marker levels are associated with greater prevalence of coronary stenosis in HIV+ men. Our findings underscore the need for further study to elucidate the relationships of inflammatory pathways with coronary artery disease in HIV+ individuals.
AB - Background-Despite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV- men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography. Methods and Results-Outcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin-6 (IL-6), intercellular adhesion molecule-1, C-reactive protein, and soluble-tumor necrosis factor-a receptor (sTNFαR) I and II (all P < 0.01) and a higher prevalence of noncalcified plaque (63% versus 54%, P=0.02) on computed tomography angiography. Among HIV+ men, for every SD increase in log-interleukin-6 and log intercellular adhesion molecule-1, there was a 30% and 60% increase, respectively, in the prevalence of coronary stenosis ≥50% (all P < 0.05). Similarly, sTNFαR I and II in HIV+ participants were associated with an increase in prevalence of coronary stenosis ≥70% (P < 0.05). Higher levels of interleukin-6, sTNFαR I, and sTNFαR II were also associated with greater coronary artery calcification score in HIV+ men (P < 0.01). Conclusions-Higher inflammatory marker levels are associated with greater prevalence of coronary stenosis in HIV+ men. Our findings underscore the need for further study to elucidate the relationships of inflammatory pathways with coronary artery disease in HIV+ individuals.
KW - Atherosclerosis
KW - Cardiac biomarkers
KW - Cardiac computed tomography
KW - Coronary artery calcium
KW - Coronary artery disease
KW - Coronary computed tomography scan
KW - Epidemiology
KW - HIV
KW - HIV infection
KW - Inflammation
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U2 - 10.1161/JAHA.116.003371
DO - 10.1161/JAHA.116.003371
M3 - Article
C2 - 27353609
AN - SCOPUS:84991523496
SN - 2047-9980
VL - 5
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 6
M1 - e003371
ER -