Inflammatory Markers and Onset of Cardiovascular Events: Results from the Health ABC Study

Matteo Cesari, Brenda W J H Penninx, Anne B. Newman, Stephen B. Kritchevsky, Barbara J. Nicklas, Kim Sutton-Tyrrell, Susan M. Rubin, Jingzhong Ding, Eleanor Marie Simonsick, Tamara B. Harris, Marco Pahor

Research output: Contribution to journalArticle

Abstract

Background - Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons. Methods and Results - The subjects were 2225 participants 70 to 79 years old, without baseline cardiovascular disease, who were enrolled in the Health, Aging, and Body Composition study. Incident coronary heart disease (CHD), stroke, and congestive heart failure (CHF) events were detected during an average follow-up of 3.6 years. Blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were assessed. After adjustment for potential confounders, IL-6 was significantly associated with all outcomes (CHD events, per IL-6 SD increase: RR, 1.27; 95% CI, 1.10 to 1.48; stroke events, per IL-6 SD increase: RR, 1.45; 95% CI, 1.12 to 1.86; CHF events, per IL-6 SD increase: RR, 1.72; 95% CI, 1.40 to 2.12). TNF-α showed significant associations with CHD (per TNF-α SD increase: RR, 1.22; 95% CI, 1.04 to 1.43) and CHF (per TNF-α SD increase: RR, 1.59; 95% CI, 1.30 to 1.95) events. CRP was significantly associated with CHF events (per CRP SD increase: RR, 1.48; 95% CI, 1.23 to 1.78). A composite summary indicator of inflammation showed a strong association with incident cardiovascular events, with an especially high risk if all 3 inflammatory markers were in the highest tertile. Conclusions - Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons.

Original languageEnglish (US)
Pages (from-to)2317-2322
Number of pages6
JournalCirculation
Volume108
Issue number19
DOIs
StatePublished - Nov 11 2003
Externally publishedYes

Fingerprint

Interleukin-6
Heart Failure
Tumor Necrosis Factor-alpha
C-Reactive Protein
Health
Coronary Disease
Cardiovascular Diseases
Stroke
Inflammation
Body Composition
Incidence

Keywords

  • Cardiovascular disease
  • Cytokines
  • Inflammation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cesari, M., Penninx, B. W. J. H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., ... Pahor, M. (2003). Inflammatory Markers and Onset of Cardiovascular Events: Results from the Health ABC Study. Circulation, 108(19), 2317-2322. https://doi.org/10.1161/01.CIR.0000097109.90783.FC

Inflammatory Markers and Onset of Cardiovascular Events : Results from the Health ABC Study. / Cesari, Matteo; Penninx, Brenda W J H; Newman, Anne B.; Kritchevsky, Stephen B.; Nicklas, Barbara J.; Sutton-Tyrrell, Kim; Rubin, Susan M.; Ding, Jingzhong; Simonsick, Eleanor Marie; Harris, Tamara B.; Pahor, Marco.

In: Circulation, Vol. 108, No. 19, 11.11.2003, p. 2317-2322.

Research output: Contribution to journalArticle

Cesari, M, Penninx, BWJH, Newman, AB, Kritchevsky, SB, Nicklas, BJ, Sutton-Tyrrell, K, Rubin, SM, Ding, J, Simonsick, EM, Harris, TB & Pahor, M 2003, 'Inflammatory Markers and Onset of Cardiovascular Events: Results from the Health ABC Study', Circulation, vol. 108, no. 19, pp. 2317-2322. https://doi.org/10.1161/01.CIR.0000097109.90783.FC
Cesari M, Penninx BWJH, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K et al. Inflammatory Markers and Onset of Cardiovascular Events: Results from the Health ABC Study. Circulation. 2003 Nov 11;108(19):2317-2322. https://doi.org/10.1161/01.CIR.0000097109.90783.FC
Cesari, Matteo ; Penninx, Brenda W J H ; Newman, Anne B. ; Kritchevsky, Stephen B. ; Nicklas, Barbara J. ; Sutton-Tyrrell, Kim ; Rubin, Susan M. ; Ding, Jingzhong ; Simonsick, Eleanor Marie ; Harris, Tamara B. ; Pahor, Marco. / Inflammatory Markers and Onset of Cardiovascular Events : Results from the Health ABC Study. In: Circulation. 2003 ; Vol. 108, No. 19. pp. 2317-2322.
@article{50a911548a704ee3871831b6291dfcf7,
title = "Inflammatory Markers and Onset of Cardiovascular Events: Results from the Health ABC Study",
abstract = "Background - Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons. Methods and Results - The subjects were 2225 participants 70 to 79 years old, without baseline cardiovascular disease, who were enrolled in the Health, Aging, and Body Composition study. Incident coronary heart disease (CHD), stroke, and congestive heart failure (CHF) events were detected during an average follow-up of 3.6 years. Blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were assessed. After adjustment for potential confounders, IL-6 was significantly associated with all outcomes (CHD events, per IL-6 SD increase: RR, 1.27; 95{\%} CI, 1.10 to 1.48; stroke events, per IL-6 SD increase: RR, 1.45; 95{\%} CI, 1.12 to 1.86; CHF events, per IL-6 SD increase: RR, 1.72; 95{\%} CI, 1.40 to 2.12). TNF-α showed significant associations with CHD (per TNF-α SD increase: RR, 1.22; 95{\%} CI, 1.04 to 1.43) and CHF (per TNF-α SD increase: RR, 1.59; 95{\%} CI, 1.30 to 1.95) events. CRP was significantly associated with CHF events (per CRP SD increase: RR, 1.48; 95{\%} CI, 1.23 to 1.78). A composite summary indicator of inflammation showed a strong association with incident cardiovascular events, with an especially high risk if all 3 inflammatory markers were in the highest tertile. Conclusions - Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons.",
keywords = "Cardiovascular disease, Cytokines, Inflammation",
author = "Matteo Cesari and Penninx, {Brenda W J H} and Newman, {Anne B.} and Kritchevsky, {Stephen B.} and Nicklas, {Barbara J.} and Kim Sutton-Tyrrell and Rubin, {Susan M.} and Jingzhong Ding and Simonsick, {Eleanor Marie} and Harris, {Tamara B.} and Marco Pahor",
year = "2003",
month = "11",
day = "11",
doi = "10.1161/01.CIR.0000097109.90783.FC",
language = "English (US)",
volume = "108",
pages = "2317--2322",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "19",

}

TY - JOUR

T1 - Inflammatory Markers and Onset of Cardiovascular Events

T2 - Results from the Health ABC Study

AU - Cesari, Matteo

AU - Penninx, Brenda W J H

AU - Newman, Anne B.

AU - Kritchevsky, Stephen B.

AU - Nicklas, Barbara J.

AU - Sutton-Tyrrell, Kim

AU - Rubin, Susan M.

AU - Ding, Jingzhong

AU - Simonsick, Eleanor Marie

AU - Harris, Tamara B.

AU - Pahor, Marco

PY - 2003/11/11

Y1 - 2003/11/11

N2 - Background - Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons. Methods and Results - The subjects were 2225 participants 70 to 79 years old, without baseline cardiovascular disease, who were enrolled in the Health, Aging, and Body Composition study. Incident coronary heart disease (CHD), stroke, and congestive heart failure (CHF) events were detected during an average follow-up of 3.6 years. Blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were assessed. After adjustment for potential confounders, IL-6 was significantly associated with all outcomes (CHD events, per IL-6 SD increase: RR, 1.27; 95% CI, 1.10 to 1.48; stroke events, per IL-6 SD increase: RR, 1.45; 95% CI, 1.12 to 1.86; CHF events, per IL-6 SD increase: RR, 1.72; 95% CI, 1.40 to 2.12). TNF-α showed significant associations with CHD (per TNF-α SD increase: RR, 1.22; 95% CI, 1.04 to 1.43) and CHF (per TNF-α SD increase: RR, 1.59; 95% CI, 1.30 to 1.95) events. CRP was significantly associated with CHF events (per CRP SD increase: RR, 1.48; 95% CI, 1.23 to 1.78). A composite summary indicator of inflammation showed a strong association with incident cardiovascular events, with an especially high risk if all 3 inflammatory markers were in the highest tertile. Conclusions - Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons.

AB - Background - Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons. Methods and Results - The subjects were 2225 participants 70 to 79 years old, without baseline cardiovascular disease, who were enrolled in the Health, Aging, and Body Composition study. Incident coronary heart disease (CHD), stroke, and congestive heart failure (CHF) events were detected during an average follow-up of 3.6 years. Blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were assessed. After adjustment for potential confounders, IL-6 was significantly associated with all outcomes (CHD events, per IL-6 SD increase: RR, 1.27; 95% CI, 1.10 to 1.48; stroke events, per IL-6 SD increase: RR, 1.45; 95% CI, 1.12 to 1.86; CHF events, per IL-6 SD increase: RR, 1.72; 95% CI, 1.40 to 2.12). TNF-α showed significant associations with CHD (per TNF-α SD increase: RR, 1.22; 95% CI, 1.04 to 1.43) and CHF (per TNF-α SD increase: RR, 1.59; 95% CI, 1.30 to 1.95) events. CRP was significantly associated with CHF events (per CRP SD increase: RR, 1.48; 95% CI, 1.23 to 1.78). A composite summary indicator of inflammation showed a strong association with incident cardiovascular events, with an especially high risk if all 3 inflammatory markers were in the highest tertile. Conclusions - Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons.

KW - Cardiovascular disease

KW - Cytokines

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=0242610488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242610488&partnerID=8YFLogxK

U2 - 10.1161/01.CIR.0000097109.90783.FC

DO - 10.1161/01.CIR.0000097109.90783.FC

M3 - Article

C2 - 14568895

AN - SCOPUS:0242610488

VL - 108

SP - 2317

EP - 2322

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 19

ER -