Inflammatory markers and depressed mood in older persons: Results from the health, aging and body composition study

Brenda W J H Penninx, Stephen B. Kritchevsky, Kristine Yaffe, Anne B. Newman, Eleanor Marie Simonsick, Susan Rubin, Luigi Ferrucci, Tamara Harris, Marco Pahor

Research output: Contribution to journalArticle

Abstract

Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95% confidence interval [CI] = 1.34-4.47) and 2.40 (95% CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.

Original languageEnglish (US)
Pages (from-to)566-572
Number of pages7
JournalBiological Psychiatry
Volume54
Issue number5
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint

Body Composition
Health
Interleukin-6
C-Reactive Protein
Lymphotoxin-beta
Confidence Intervals
Depression
Epidemiologic Studies
Tumor Necrosis Factor-alpha
Demography
Cytokines
Inflammation
Serum

Keywords

  • C-reactive protein
  • Depression
  • Inflammation
  • Interleukin-6
  • Old age
  • Tumor necrosis factor α

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Inflammatory markers and depressed mood in older persons : Results from the health, aging and body composition study. / Penninx, Brenda W J H; Kritchevsky, Stephen B.; Yaffe, Kristine; Newman, Anne B.; Simonsick, Eleanor Marie; Rubin, Susan; Ferrucci, Luigi; Harris, Tamara; Pahor, Marco.

In: Biological Psychiatry, Vol. 54, No. 5, 01.09.2003, p. 566-572.

Research output: Contribution to journalArticle

Penninx, BWJH, Kritchevsky, SB, Yaffe, K, Newman, AB, Simonsick, EM, Rubin, S, Ferrucci, L, Harris, T & Pahor, M 2003, 'Inflammatory markers and depressed mood in older persons: Results from the health, aging and body composition study', Biological Psychiatry, vol. 54, no. 5, pp. 566-572. https://doi.org/10.1016/S0006-3223(02)01811-5
Penninx, Brenda W J H ; Kritchevsky, Stephen B. ; Yaffe, Kristine ; Newman, Anne B. ; Simonsick, Eleanor Marie ; Rubin, Susan ; Ferrucci, Luigi ; Harris, Tamara ; Pahor, Marco. / Inflammatory markers and depressed mood in older persons : Results from the health, aging and body composition study. In: Biological Psychiatry. 2003 ; Vol. 54, No. 5. pp. 566-572.
@article{ce9478263c5f47e08fafea09cf85a4be,
title = "Inflammatory markers and depressed mood in older persons: Results from the health, aging and body composition study",
abstract = "Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95{\%} confidence interval [CI] = 1.34-4.47) and 2.40 (95{\%} CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.",
keywords = "C-reactive protein, Depression, Inflammation, Interleukin-6, Old age, Tumor necrosis factor α",
author = "Penninx, {Brenda W J H} and Kritchevsky, {Stephen B.} and Kristine Yaffe and Newman, {Anne B.} and Simonsick, {Eleanor Marie} and Susan Rubin and Luigi Ferrucci and Tamara Harris and Marco Pahor",
year = "2003",
month = "9",
day = "1",
doi = "10.1016/S0006-3223(02)01811-5",
language = "English (US)",
volume = "54",
pages = "566--572",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Inflammatory markers and depressed mood in older persons

T2 - Results from the health, aging and body composition study

AU - Penninx, Brenda W J H

AU - Kritchevsky, Stephen B.

AU - Yaffe, Kristine

AU - Newman, Anne B.

AU - Simonsick, Eleanor Marie

AU - Rubin, Susan

AU - Ferrucci, Luigi

AU - Harris, Tamara

AU - Pahor, Marco

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95% confidence interval [CI] = 1.34-4.47) and 2.40 (95% CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.

AB - Background: Patients with major depression have elevated levels of inflammatory cytokines. We examined the link between inflammatory markers and depressed mood in a community-based sample of older people. Methods: Data are from 3024 well-functioning older persons, 70-79 years of age, participating in the Health, Aging and Body Composition study. Depressed mood was defined as a Center for Epidemiologic Studies Depression scale score of 16 or higher. Plasma concentrations of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) were measured. Results: Compared with the 2879 nondepressed subjects, the 145 persons with depressed mood had higher median plasma levels of IL-6 (2.04 vs. 1.83 pg/mL, p = .02), TNF-α (3.43 vs. 3. 16 pg/mL, p = .05), and CRP (1.96 vs. 1.66 mg/L, p = .03). After adjustment for health and demographic variables, depressed mood was especially prevalent among persons who had a high (above median) plasma level for at least two of the inflammatory markers. Compared with those without high levels, for persons with a high level for two or all three markers the risk of depressed mood was 2.45 (95% confidence interval [CI] = 1.34-4.47) and 2.40 (95% CI = 1.27-4.53), respectively. The association between depressed mood and serum level of IL-6 was significantly stronger in men than in women. Conclusions: In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation.

KW - C-reactive protein

KW - Depression

KW - Inflammation

KW - Interleukin-6

KW - Old age

KW - Tumor necrosis factor α

UR - http://www.scopus.com/inward/record.url?scp=0142042989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142042989&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(02)01811-5

DO - 10.1016/S0006-3223(02)01811-5

M3 - Article

C2 - 12946885

AN - SCOPUS:0142042989

VL - 54

SP - 566

EP - 572

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 5

ER -