Inflammatory markers and cognition in well-functioning African-American and white elders

K. Yaffe, K. Lindquist, Penninx, Eleanor Marie Simonsick, M. Pahor, S. Kritchevsky, L. Launer, L. Kuller, S. Rubin, T. Harris

Research output: Contribution to journalArticle

Abstract

Background: Several lines of evidence suggest that inflammatory mechanisms contribute to AD. Objective: To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. Methods: The authors studied 3,031 African-American and white men and women (mean age 74 years) enrolled in the Health, Aging, and Body Composition Study. Serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) and plasma levels of tumor necrosis factor-α (TNFα) were measured at baseline; cognition was assessed with the Modified Mini-Mental State Examination (3MS) at baseline and at follow-up. Cognitive decline was defined as a decline of >5 points. Results: In age-adjusted analyses, participants in the highest tertile of IL-6 or CRP performed nearly 2 points lower (worse) on baseline and follow-up 3MS (p <0.001 for all) and declined by almost 1 point over the >2 years (p = 0.01 for IL-6 and p = 0.04 for CRP) compared with those in the lowest tertile. After multivariate adjustment, 3MS scores among participants in the highest tertile of IL-6 and CRP were similar at baseline but remained significantly lower at follow-up (p ≤ 5 0.05 for both). Those in the highest inflammatory marker tertile were also more likely to have cognitive decline compared with the lowest tertile for IL-6 (26 vs 20%; age-adjusted odds ratio [OR] = 1.34; 95% CI 1.06 to 1.69) and for CRP (24 vs 19%; OR = 1.41; 95% CI 1.10 to 1.79) but not for TNFα (23 vs 21%; OR = 1.12; 95% CI 0.88 to 1.43). There was no significant interaction between race and inflammatory marker or between nonsteroidal anti-inflammatory drug use and inflammatory marker on cognition. Conclusions: Serum markers of inflammation, especially IL-6 and CRP, are prospectively associated with cognitive decline in well-functioning elders. These findings support the hypothesis that inflammation contributes to cognitive decline in the elderly.

Original languageEnglish (US)
Pages (from-to)76-80
Number of pages5
JournalNeurology
Volume61
Issue number1
StatePublished - Jul 8 2003
Externally publishedYes

Fingerprint

African Americans
C-Reactive Protein
Cognition
Interleukin-6
Odds Ratio
Inflammation
Tumor Necrosis Factor-alpha
Social Adjustment
Body Composition
Anti-Inflammatory Agents
Biomarkers
Cognitive Dysfunction
Health
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yaffe, K., Lindquist, K., Penninx, Simonsick, E. M., Pahor, M., Kritchevsky, S., ... Harris, T. (2003). Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology, 61(1), 76-80.

Inflammatory markers and cognition in well-functioning African-American and white elders. / Yaffe, K.; Lindquist, K.; Penninx, ; Simonsick, Eleanor Marie; Pahor, M.; Kritchevsky, S.; Launer, L.; Kuller, L.; Rubin, S.; Harris, T.

In: Neurology, Vol. 61, No. 1, 08.07.2003, p. 76-80.

Research output: Contribution to journalArticle

Yaffe, K, Lindquist, K, Penninx, , Simonsick, EM, Pahor, M, Kritchevsky, S, Launer, L, Kuller, L, Rubin, S & Harris, T 2003, 'Inflammatory markers and cognition in well-functioning African-American and white elders', Neurology, vol. 61, no. 1, pp. 76-80.
Yaffe K, Lindquist K, Penninx , Simonsick EM, Pahor M, Kritchevsky S et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003 Jul 8;61(1):76-80.
Yaffe, K. ; Lindquist, K. ; Penninx, ; Simonsick, Eleanor Marie ; Pahor, M. ; Kritchevsky, S. ; Launer, L. ; Kuller, L. ; Rubin, S. ; Harris, T. / Inflammatory markers and cognition in well-functioning African-American and white elders. In: Neurology. 2003 ; Vol. 61, No. 1. pp. 76-80.
@article{2de05dfd7524433abd89de5c884ce093,
title = "Inflammatory markers and cognition in well-functioning African-American and white elders",
abstract = "Background: Several lines of evidence suggest that inflammatory mechanisms contribute to AD. Objective: To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. Methods: The authors studied 3,031 African-American and white men and women (mean age 74 years) enrolled in the Health, Aging, and Body Composition Study. Serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) and plasma levels of tumor necrosis factor-α (TNFα) were measured at baseline; cognition was assessed with the Modified Mini-Mental State Examination (3MS) at baseline and at follow-up. Cognitive decline was defined as a decline of >5 points. Results: In age-adjusted analyses, participants in the highest tertile of IL-6 or CRP performed nearly 2 points lower (worse) on baseline and follow-up 3MS (p <0.001 for all) and declined by almost 1 point over the >2 years (p = 0.01 for IL-6 and p = 0.04 for CRP) compared with those in the lowest tertile. After multivariate adjustment, 3MS scores among participants in the highest tertile of IL-6 and CRP were similar at baseline but remained significantly lower at follow-up (p ≤ 5 0.05 for both). Those in the highest inflammatory marker tertile were also more likely to have cognitive decline compared with the lowest tertile for IL-6 (26 vs 20{\%}; age-adjusted odds ratio [OR] = 1.34; 95{\%} CI 1.06 to 1.69) and for CRP (24 vs 19{\%}; OR = 1.41; 95{\%} CI 1.10 to 1.79) but not for TNFα (23 vs 21{\%}; OR = 1.12; 95{\%} CI 0.88 to 1.43). There was no significant interaction between race and inflammatory marker or between nonsteroidal anti-inflammatory drug use and inflammatory marker on cognition. Conclusions: Serum markers of inflammation, especially IL-6 and CRP, are prospectively associated with cognitive decline in well-functioning elders. These findings support the hypothesis that inflammation contributes to cognitive decline in the elderly.",
author = "K. Yaffe and K. Lindquist and Penninx and Simonsick, {Eleanor Marie} and M. Pahor and S. Kritchevsky and L. Launer and L. Kuller and S. Rubin and T. Harris",
year = "2003",
month = "7",
day = "8",
language = "English (US)",
volume = "61",
pages = "76--80",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Inflammatory markers and cognition in well-functioning African-American and white elders

AU - Yaffe, K.

AU - Lindquist, K.

AU - Penninx,

AU - Simonsick, Eleanor Marie

AU - Pahor, M.

AU - Kritchevsky, S.

AU - Launer, L.

AU - Kuller, L.

AU - Rubin, S.

AU - Harris, T.

PY - 2003/7/8

Y1 - 2003/7/8

N2 - Background: Several lines of evidence suggest that inflammatory mechanisms contribute to AD. Objective: To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. Methods: The authors studied 3,031 African-American and white men and women (mean age 74 years) enrolled in the Health, Aging, and Body Composition Study. Serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) and plasma levels of tumor necrosis factor-α (TNFα) were measured at baseline; cognition was assessed with the Modified Mini-Mental State Examination (3MS) at baseline and at follow-up. Cognitive decline was defined as a decline of >5 points. Results: In age-adjusted analyses, participants in the highest tertile of IL-6 or CRP performed nearly 2 points lower (worse) on baseline and follow-up 3MS (p <0.001 for all) and declined by almost 1 point over the >2 years (p = 0.01 for IL-6 and p = 0.04 for CRP) compared with those in the lowest tertile. After multivariate adjustment, 3MS scores among participants in the highest tertile of IL-6 and CRP were similar at baseline but remained significantly lower at follow-up (p ≤ 5 0.05 for both). Those in the highest inflammatory marker tertile were also more likely to have cognitive decline compared with the lowest tertile for IL-6 (26 vs 20%; age-adjusted odds ratio [OR] = 1.34; 95% CI 1.06 to 1.69) and for CRP (24 vs 19%; OR = 1.41; 95% CI 1.10 to 1.79) but not for TNFα (23 vs 21%; OR = 1.12; 95% CI 0.88 to 1.43). There was no significant interaction between race and inflammatory marker or between nonsteroidal anti-inflammatory drug use and inflammatory marker on cognition. Conclusions: Serum markers of inflammation, especially IL-6 and CRP, are prospectively associated with cognitive decline in well-functioning elders. These findings support the hypothesis that inflammation contributes to cognitive decline in the elderly.

AB - Background: Several lines of evidence suggest that inflammatory mechanisms contribute to AD. Objective: To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. Methods: The authors studied 3,031 African-American and white men and women (mean age 74 years) enrolled in the Health, Aging, and Body Composition Study. Serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) and plasma levels of tumor necrosis factor-α (TNFα) were measured at baseline; cognition was assessed with the Modified Mini-Mental State Examination (3MS) at baseline and at follow-up. Cognitive decline was defined as a decline of >5 points. Results: In age-adjusted analyses, participants in the highest tertile of IL-6 or CRP performed nearly 2 points lower (worse) on baseline and follow-up 3MS (p <0.001 for all) and declined by almost 1 point over the >2 years (p = 0.01 for IL-6 and p = 0.04 for CRP) compared with those in the lowest tertile. After multivariate adjustment, 3MS scores among participants in the highest tertile of IL-6 and CRP were similar at baseline but remained significantly lower at follow-up (p ≤ 5 0.05 for both). Those in the highest inflammatory marker tertile were also more likely to have cognitive decline compared with the lowest tertile for IL-6 (26 vs 20%; age-adjusted odds ratio [OR] = 1.34; 95% CI 1.06 to 1.69) and for CRP (24 vs 19%; OR = 1.41; 95% CI 1.10 to 1.79) but not for TNFα (23 vs 21%; OR = 1.12; 95% CI 0.88 to 1.43). There was no significant interaction between race and inflammatory marker or between nonsteroidal anti-inflammatory drug use and inflammatory marker on cognition. Conclusions: Serum markers of inflammation, especially IL-6 and CRP, are prospectively associated with cognitive decline in well-functioning elders. These findings support the hypothesis that inflammation contributes to cognitive decline in the elderly.

UR - http://www.scopus.com/inward/record.url?scp=10744223280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744223280&partnerID=8YFLogxK

M3 - Article

VL - 61

SP - 76

EP - 80

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 1

ER -