Inflammatory gene variants and the risk of biliary tract cancers and stones: A population-based study in China

Felipe A. Castro, Jill Koshiol, Ann W. Hsing, Yu Tang Gao, Asif Rashid, Lisa W. Chu, Ming Chang Shen, Bing Shen Wang, Tian Qua Han, Bai He Zhang, Shelley Niwa, Kai Yu, Hong Zhang, Stephen Chanock, Gabriella Andreotti

Research output: Contribution to journalArticle

Abstract

Background: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.Methods: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.Results: Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).Conclusion: These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.

Original languageEnglish (US)
Article number468
JournalBMC cancer
Volume12
DOIs
StatePublished - Oct 11 2012
Externally publishedYes

Keywords

  • Biliary stones
  • Biliary tract cancer
  • Genetic susceptibility
  • Inflammation

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

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  • Cite this

    Castro, F. A., Koshiol, J., Hsing, A. W., Gao, Y. T., Rashid, A., Chu, L. W., Shen, M. C., Wang, B. S., Han, T. Q., Zhang, B. H., Niwa, S., Yu, K., Zhang, H., Chanock, S., & Andreotti, G. (2012). Inflammatory gene variants and the risk of biliary tract cancers and stones: A population-based study in China. BMC cancer, 12, [468]. https://doi.org/10.1186/1471-2407-12-468