Abstract
Modern toxicology has embraced in vitro methods, and major hopes are based on the Omics technologies and systems biology approaches they bring along (Hartung and McBride in ALTEX 28(2):83-93, 2011; Hartung et al. in ALTEX 29(2):119-28, 2012). A culture of stringent validation has been developed for such approaches (Leist et al. in ALTEX 27(4):309-317, 2010; ALTEX 29(4):373-88, 2012a; Toxicol Res 1:8-22, 2012b), while the quality and usefulness of animal experiments have been little scrutinized. A new study (Seok et al. 2013) now shows the low predictivity of animal responses in the field of inflammation. These findings corroborate earlier findings from comparisons in the fields of neurodegeneration, stroke and sepsis. The low predictivity of animal experiments in research areas allowing direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key technology to predict human safety.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 563-567 |
| Number of pages | 5 |
| Journal | Archives of Toxicology |
| Volume | 87 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2013 |
Fingerprint
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Inflammatory findings on species extrapolations : Humans are definitely no 70-kg mice. / Leist, Marcel; Hartung, Thomas.
In: Archives of Toxicology, Vol. 87, No. 4, 04.2013, p. 563-567.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inflammatory findings on species extrapolations
T2 - Humans are definitely no 70-kg mice
AU - Leist, Marcel
AU - Hartung, Thomas
PY - 2013/4
Y1 - 2013/4
N2 - Modern toxicology has embraced in vitro methods, and major hopes are based on the Omics technologies and systems biology approaches they bring along (Hartung and McBride in ALTEX 28(2):83-93, 2011; Hartung et al. in ALTEX 29(2):119-28, 2012). A culture of stringent validation has been developed for such approaches (Leist et al. in ALTEX 27(4):309-317, 2010; ALTEX 29(4):373-88, 2012a; Toxicol Res 1:8-22, 2012b), while the quality and usefulness of animal experiments have been little scrutinized. A new study (Seok et al. 2013) now shows the low predictivity of animal responses in the field of inflammation. These findings corroborate earlier findings from comparisons in the fields of neurodegeneration, stroke and sepsis. The low predictivity of animal experiments in research areas allowing direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key technology to predict human safety.
AB - Modern toxicology has embraced in vitro methods, and major hopes are based on the Omics technologies and systems biology approaches they bring along (Hartung and McBride in ALTEX 28(2):83-93, 2011; Hartung et al. in ALTEX 29(2):119-28, 2012). A culture of stringent validation has been developed for such approaches (Leist et al. in ALTEX 27(4):309-317, 2010; ALTEX 29(4):373-88, 2012a; Toxicol Res 1:8-22, 2012b), while the quality and usefulness of animal experiments have been little scrutinized. A new study (Seok et al. 2013) now shows the low predictivity of animal responses in the field of inflammation. These findings corroborate earlier findings from comparisons in the fields of neurodegeneration, stroke and sepsis. The low predictivity of animal experiments in research areas allowing direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key technology to predict human safety.
UR - http://www.scopus.com/inward/record.url?scp=84876685425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876685425&partnerID=8YFLogxK
U2 - 10.1007/s00204-013-1038-0
DO - 10.1007/s00204-013-1038-0
M3 - Article
C2 - 23503654
AN - SCOPUS:84876685425
VL - 87
SP - 563
EP - 567
JO - Archiv fur Toxikologie
JF - Archiv fur Toxikologie
SN - 0003-9446
IS - 4
ER -