Inflammatory findings on species extrapolations: Humans are definitely no 70-kg mice

Marcel Leist, Thomas Hartung

Research output: Contribution to journalArticle

Abstract

Modern toxicology has embraced in vitro methods, and major hopes are based on the Omics technologies and systems biology approaches they bring along (Hartung and McBride in ALTEX 28(2):83-93, 2011; Hartung et al. in ALTEX 29(2):119-28, 2012). A culture of stringent validation has been developed for such approaches (Leist et al. in ALTEX 27(4):309-317, 2010; ALTEX 29(4):373-88, 2012a; Toxicol Res 1:8-22, 2012b), while the quality and usefulness of animal experiments have been little scrutinized. A new study (Seok et al. 2013) now shows the low predictivity of animal responses in the field of inflammation. These findings corroborate earlier findings from comparisons in the fields of neurodegeneration, stroke and sepsis. The low predictivity of animal experiments in research areas allowing direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key technology to predict human safety.

Original languageEnglish (US)
Pages (from-to)563-567
Number of pages5
JournalArchives of Toxicology
Volume87
Issue number4
DOIs
StatePublished - Apr 2013

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Extrapolation
Animals
Technology
Systems Biology
Toxicology
Sepsis
Stroke
Inflammation
Safety
Research
Experiments
In Vitro Techniques

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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Inflammatory findings on species extrapolations : Humans are definitely no 70-kg mice. / Leist, Marcel; Hartung, Thomas.

In: Archives of Toxicology, Vol. 87, No. 4, 04.2013, p. 563-567.

Research output: Contribution to journalArticle

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