Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

Malcolm J. Avison; Avindra Nath; Robin Greene-Avison; Frederick A. Schmitt; Rodney A. Bales; As'ad Ethisham; Richard N. Greenberg; Joseph R. Berger

doi:10.1080/13550280490463532

Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

Malcolm J. Avison, Avindra Nath, Robin Greene-Avison, Frederick A. Schmitt, Rodney A. Bales, As'ad Ethisham, Richard N. Greenberg, Joseph R. Berger

School of Medicine

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Increased postcontrast enhancement in contrast-enhanced magnetic resonance imaging (CE-MRI) of the central nervous system (CNS) is a predictor of human immunodeficiency virus (HIV) dementia severity in HIV-infected subjects. The present study confirms this earlier finding in a mildly impaired patient cohort, and demonstrates that the increased postcontrast enhancement is correlated with increased cerebrospinal fluid (CSF) levels of monocyte chemoattractant protein (MCP)-1, an inflammatory chemokine, and increased CNS levels of mI, a microglial marker. These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia.

Original language	English (US)
Pages (from-to)	223-232
Number of pages	10
Journal	Journal of neurovirology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1080/13550280490463532
State	Published - Aug 2004

Keywords

AIDS
Blood-brain barrier (BBB)
CNS
HIV dementia
Inflammation
Magnetic resonance
Magnetic resonance imaging (MRI)
Magnetic resonance spectroscopy (MRS)

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.1080/13550280490463532

Cite this

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abstract = "Increased postcontrast enhancement in contrast-enhanced magnetic resonance imaging (CE-MRI) of the central nervous system (CNS) is a predictor of human immunodeficiency virus (HIV) dementia severity in HIV-infected subjects. The present study confirms this earlier finding in a mildly impaired patient cohort, and demonstrates that the increased postcontrast enhancement is correlated with increased cerebrospinal fluid (CSF) levels of monocyte chemoattractant protein (MCP)-1, an inflammatory chemokine, and increased CNS levels of mI, a microglial marker. These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia.",

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AU - Nath, Avindra

AU - Greene-Avison, Robin

AU - Schmitt, Frederick A.

AU - Bales, Rodney A.

AU - Ethisham, As'ad

AU - Greenberg, Richard N.

AU - Berger, Joseph R.

PY - 2004/8

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AB - Increased postcontrast enhancement in contrast-enhanced magnetic resonance imaging (CE-MRI) of the central nervous system (CNS) is a predictor of human immunodeficiency virus (HIV) dementia severity in HIV-infected subjects. The present study confirms this earlier finding in a mildly impaired patient cohort, and demonstrates that the increased postcontrast enhancement is correlated with increased cerebrospinal fluid (CSF) levels of monocyte chemoattractant protein (MCP)-1, an inflammatory chemokine, and increased CNS levels of mI, a microglial marker. These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia.

KW - AIDS

KW - Blood-brain barrier (BBB)

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KW - Magnetic resonance imaging (MRI)

KW - Magnetic resonance spectroscopy (MRS)

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Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

Abstract

Keywords

ASJC Scopus subject areas

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