Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

Malcolm J. Avison, Avindra Nath, Robin Greene-Avison, Frederick A. Schmitt, Rodney A. Bales, As'ad Ethisham, Richard N. Greenberg, Joseph R. Berger

Research output: Contribution to journalArticlepeer-review

Abstract

Increased postcontrast enhancement in contrast-enhanced magnetic resonance imaging (CE-MRI) of the central nervous system (CNS) is a predictor of human immunodeficiency virus (HIV) dementia severity in HIV-infected subjects. The present study confirms this earlier finding in a mildly impaired patient cohort, and demonstrates that the increased postcontrast enhancement is correlated with increased cerebrospinal fluid (CSF) levels of monocyte chemoattractant protein (MCP)-1, an inflammatory chemokine, and increased CNS levels of mI, a microglial marker. These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
JournalJournal of neurovirology
Volume10
Issue number4
DOIs
StatePublished - Aug 2004

Keywords

  • AIDS
  • Blood-brain barrier (BBB)
  • CNS
  • HIV dementia
  • Inflammation
  • Magnetic resonance
  • Magnetic resonance imaging (MRI)
  • Magnetic resonance spectroscopy (MRS)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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