Inflammatory cell types and clinical features of interstitial cystitis

Deborah R. Erickson, Deborah A Belchis, David J. Dabbs

Research output: Contribution to journalArticle

Abstract

Purpose: We tested whether the types of inflammatory cells seen on bladder biopsies were associated with other clinical features and urinary markers of interstitial cystitis. Materials and Methods: Bladder biopsies from 30 interstitial cystitis patients were evaluated by immunohistochemical staining for T cells, B cells, macrophages and human leukocyte antigen-DR positive cells. These findings were tested for associations with clinical features and urinary markers of interstitial cystitis using a = 0.01 because multiple tests were performed. Results: Overall severity of inflammation was significantly associated with age at symptom onset, symptom relief after bladder distention and urinary interleukin-6 levels. Patients with severe inflammation had trends toward smaller bladder capacity under anesthesia, increased bladder vascularity and mucosal cracks, lower urinary MUC-1 glycoprotein levels and absence of bloating as a symptom. B cell staining was significantly associated with severe inflammation, symptom relief after distention and absence of bloating as a symptom. T cell staining was significantly associated with severe inflammation and age at symptom onset. Human leukocyte antigert-DR staining had trends with symptoms, including presence of bloating, constant urge to void and absence of burning. Macrophage staining did not associate with any features tested at the α = 0.05 level. Conclusions: Interstitial cystitis patients with severe inflammation have different age, treatment response and urinary marker levels than those with mild inflammation. These findings suggest that the 2 patient groups have different underlying pathophysiologies. The significant associations for T and B cell staining were similar to those for overall inflammation.

Original languageEnglish (US)
Pages (from-to)790-794
Number of pages5
JournalJournal of Urology
Volume158
Issue number3
DOIs
StatePublished - Sep 1997
Externally publishedYes

Keywords

  • Cells
  • Cystitis
  • Inflammation

ASJC Scopus subject areas

  • Urology

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