Inflammatory bowel disease associated neoplasia: A surgeon's perspective

Azah A. Althumairi, Mark G. Lazarev, Susan L. Gearhart

Research output: Contribution to journalReview article

Abstract

Inflammatory bowel disease (IBD) is associated with increased risk of colorectal cancer (CRC). The risk is known to increase with longer duration of the disease, family history of CRC, and history of primary sclerosing cholangitis. The diagnosis of the neoplastic changes associated with IBD is difficult owing to the heterogeneous endoscopic appearance and interobserver variability of the pathological diagnosis. Screening and surveillance guidelines have been established which aim for early detection of neoplasia. Several surgical options are available for the treatment of IBD-associated neoplasia. Patients' morbidities, risk factors for CRC, degree and the extent of neoplasia must be considered in choosing the surgical treatment. A multidisciplinary team including the surgeon, gastroenterologist, pathologist, and the patient who has a clear understanding of the nature of their disease is needed to optimize outcomes.

Original languageEnglish (US)
Pages (from-to)961-973
Number of pages13
JournalWorld Journal of Gastroenterology
Volume22
Issue number3
DOIs
StatePublished - Jan 21 2016

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Keywords

  • Colectomy
  • Colorectal cancer
  • Dysplasia
  • Endoscopy
  • Inflammatory bowel disease
  • Surveillance

ASJC Scopus subject areas

  • Gastroenterology

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