Inflammatory and immunological parameters in children with haemolytic uremic syndrome (HUS) and gastroenteritis - Pathophysiological and diagnostic clues

Sören Westerholt, Thomas Hartung, Martin Tollens, Andrea Güstrau, Mathias Oberhoffer, Helge Karch, Bernd Klare, Klaus Pfeffer, Peter Emmrich, Renate Oberhoffer

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to identify parameters indicating a risk for developing typical haemolytic uremic syndrome (D + HUS) during the prodromal phase of diarrhea caused by enterohaemorrhagic Escherichia coli (EHEC). Forty-eight children were studied prospectively with regard to inflammatory serum factors on admission to hospital. Ten patients developed D + HUS (group I), 15 suffered from viral-gastroenteritis (group IIa) and 23 from other types of bacterial gastroenteritis (group IIb). Mean levels of IL-8 tended to be elevated in group I compared to groups IIa and IIb. Neopterin and IL-10 levels particularly were significantly decreased in HUS in comparison to both gastroenteritis groups. Low IL-10 levels indicate a substantial disregulation of the immune response in HUS, as IL-10 downregulates the pro-inflammatory response and suppresses pro-coagulant activity in experimental endotoxemia. Our results suggest low neopterin, high IL-8 and especially low IL-10 levels are indicators of a high risk for developing HUS. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)822-827
Number of pages6
JournalCytokine
Volume12
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

Keywords

  • Enterohaemorrhagic E. coli
  • Haemolytic uremic syndrome
  • Interleukin 8
  • Interleukin-10
  • Neopterin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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