Abstract
The objective of this study was to identify parameters indicating a risk for developing typical haemolytic uremic syndrome (D + HUS) during the prodromal phase of diarrhea caused by enterohaemorrhagic Escherichia coli (EHEC). Forty-eight children were studied prospectively with regard to inflammatory serum factors on admission to hospital. Ten patients developed D + HUS (group I), 15 suffered from viral-gastroenteritis (group IIa) and 23 from other types of bacterial gastroenteritis (group IIb). Mean levels of IL-8 tended to be elevated in group I compared to groups IIa and IIb. Neopterin and IL-10 levels particularly were significantly decreased in HUS in comparison to both gastroenteritis groups. Low IL-10 levels indicate a substantial disregulation of the immune response in HUS, as IL-10 downregulates the pro-inflammatory response and suppresses pro-coagulant activity in experimental endotoxemia. Our results suggest low neopterin, high IL-8 and especially low IL-10 levels are indicators of a high risk for developing HUS. (C) 2000 Academic Press.
Original language | English (US) |
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Pages (from-to) | 822-827 |
Number of pages | 6 |
Journal | Cytokine |
Volume | 12 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2000 |
Externally published | Yes |
Keywords
- Enterohaemorrhagic E. coli
- Haemolytic uremic syndrome
- Interleukin 8
- Interleukin-10
- Neopterin
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Biochemistry
- Molecular Biology
- Hematology