Inflammation-related gene polymorphisms and colorectal adenoma

Marc J. Gunter, Federico Canzian, Stefano Landi, Stephen J. Chanock, Rashmi Sinha, Nathaniel Rothman

Research output: Contribution to journalArticle

Abstract

Chronic inflammation has been reported to be a risk factor for colorectal neoplasia. The propensity to mount an inflammatory response is modified by germ line variation in cytokine and other inflammation-related genes. We hypothesized that a proinflammatory genotype would be positively associated with colorectal adenoma, a precursor of colorectal cancer. We investigated the association of colorectal adenoma with 19 single nucleotide polymorphisms in a range of important proinflammatory (IL1B, IL6, IL8, TNF, and LTA) and anti-inflammatory (IL4, IL10, and IL13) cytokines and other inflammation-related genes (PTGS2 and PPARG) in a case-control study of risk factors for colorectal polyps in which all participants (ages 18-74 years) had undergone colonoscopy or sigmoidoscopy. The study sample comprised 244 cases of colorectal adenoma and 231 polyp-free controls. Compared with being homozygous for the common allele, heterozygosity at the IL1B -31 (C>T) locus was associated with an odds ratio (OR) for colorectal adenoma of 1.8 [95% confidence interval (95% CI), 1.2-2.9]. Homozygous carriers of the IL8 -251-A allele were at 2.7-fold increased risk of adenoma (95% CI, 1.5-4.9) compared with homozygosity for the common T allele, whereas carriage of at least one IL8 -251-A allele conferred a 1.5 increased odds of disease (95% CI, 1.0-2.4). Among non-nonsteroidal anti-inflammatory drug users, there was a statistically significant association between the IL10 -819-T/T genotype and adenoma compared with the common IL10 -819-C/C genotype (OR, 3.9; 95% CI, 1.1-13.6), which was not evident among nonsteroidal anti-inflammatory drug users (OR, 0.7; 95% CI, 0.3-1.5; Pinteraction = 0.01). These exploratory data provide evidence that polymorphic variation in genes that regulate inflammation could alter risk for colorectal adenoma.

Original languageEnglish (US)
Pages (from-to)1126-1131
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Fingerprint

Adenoma
Inflammation
Confidence Intervals
Genes
Alleles
Interleukin-8
Interleukin-10
Anti-Inflammatory Agents
Odds Ratio
Genotype
Polyps
Drug Users
Cytokines
Sigmoidoscopy
Interleukin-13
Cyclooxygenase 2
Colonoscopy
Germ Cells
Interleukin-4
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Gunter, M. J., Canzian, F., Landi, S., Chanock, S. J., Sinha, R., & Rothman, N. (2006). Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiology Biomarkers and Prevention, 15(6), 1126-1131. https://doi.org/10.1158/1055-9965.EPI-06-0042

Inflammation-related gene polymorphisms and colorectal adenoma. / Gunter, Marc J.; Canzian, Federico; Landi, Stefano; Chanock, Stephen J.; Sinha, Rashmi; Rothman, Nathaniel.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 6, 06.2006, p. 1126-1131.

Research output: Contribution to journalArticle

Gunter, MJ, Canzian, F, Landi, S, Chanock, SJ, Sinha, R & Rothman, N 2006, 'Inflammation-related gene polymorphisms and colorectal adenoma', Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 6, pp. 1126-1131. https://doi.org/10.1158/1055-9965.EPI-06-0042
Gunter, Marc J. ; Canzian, Federico ; Landi, Stefano ; Chanock, Stephen J. ; Sinha, Rashmi ; Rothman, Nathaniel. / Inflammation-related gene polymorphisms and colorectal adenoma. In: Cancer Epidemiology Biomarkers and Prevention. 2006 ; Vol. 15, No. 6. pp. 1126-1131.
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