@article{79a8cdd5ce594a518e394f98fb238fec,
title = "Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring",
abstract = "Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1+/-) mothers, fetuses, and offspring. We show that alterations in fetal liver and spleen HO homeostasis during inflammation late in gestation can lead to a sustained dysregulation of innate immune cell populations and intracellular myeloid HO-1 expression in the spleen through young adolescence [postnatal day 25] in mice.",
author = "Maide Ozen and Hui Zhao and Flora Kalish and Yang Yang and Jantzie, {Lauren L.} and Wong, {Ronald J.} and Stevenson, {David K.}",
note = "Funding Information: This research was funded by Mary L. Johnson Research Fund, Christopher Hess Research Fund, March of Dimes Prematurity Research Center at Stanford University (DKS). Dr. Maide Ozen was supported by Ruth L Kirschstein National Research Service Award, Parent T32, grant number NIH/NICHD; 5T32 HD007249-30 (DKS). The sponsors or funders did not play any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2021 Ozen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2021",
month = jun,
doi = "10.1371/journal.pone.0252642",
language = "English (US)",
volume = "16",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6 June",
}