Inflammation in the etiology of prostate cancer: An epidemiologic perspective

Siobhan Sutcliffe, Elizabeth A Platz

Research output: Contribution to journalArticle

Abstract

The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.

Original languageEnglish (US)
Pages (from-to)242-249
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Volume25
Issue number3
DOIs
StatePublished - May 2007

Fingerprint

Prostatic Neoplasms
Inflammation
Prostatitis
Calculi
Sexually Transmitted Diseases
Epidemiologic Studies
Anti-Inflammatory Agents
Prospective Studies
Pharmaceutical Preparations
Genes
Clinical Studies

Keywords

  • Epidemiology
  • Immune response
  • Inflammation
  • Nonsteroidal antiinflammatory drugs
  • Prostate cancer
  • Prostatitis
  • Sexually transmitted infections

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Inflammation in the etiology of prostate cancer : An epidemiologic perspective. / Sutcliffe, Siobhan; Platz, Elizabeth A.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 25, No. 3, 05.2007, p. 242-249.

Research output: Contribution to journalArticle

@article{33a7f0c64e4b43f097e5f6cd822e1df6,
title = "Inflammation in the etiology of prostate cancer: An epidemiologic perspective",
abstract = "The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.",
keywords = "Epidemiology, Immune response, Inflammation, Nonsteroidal antiinflammatory drugs, Prostate cancer, Prostatitis, Sexually transmitted infections",
author = "Siobhan Sutcliffe and Platz, {Elizabeth A}",
year = "2007",
month = "5",
doi = "10.1016/j.urolonc.2006.09.014",
language = "English (US)",
volume = "25",
pages = "242--249",
journal = "Urologic Oncology",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Inflammation in the etiology of prostate cancer

T2 - An epidemiologic perspective

AU - Sutcliffe, Siobhan

AU - Platz, Elizabeth A

PY - 2007/5

Y1 - 2007/5

N2 - The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.

AB - The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.

KW - Epidemiology

KW - Immune response

KW - Inflammation

KW - Nonsteroidal antiinflammatory drugs

KW - Prostate cancer

KW - Prostatitis

KW - Sexually transmitted infections

UR - http://www.scopus.com/inward/record.url?scp=34247579199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247579199&partnerID=8YFLogxK

U2 - 10.1016/j.urolonc.2006.09.014

DO - 10.1016/j.urolonc.2006.09.014

M3 - Article

C2 - 17483023

AN - SCOPUS:34247579199

VL - 25

SP - 242

EP - 249

JO - Urologic Oncology

JF - Urologic Oncology

SN - 1078-1439

IS - 3

ER -