TY - JOUR
T1 - Inflammation in the etiology of prostate cancer
T2 - An epidemiologic perspective
AU - Sutcliffe, Siobhan
AU - Platz, Elizabeth A.
N1 - Funding Information:
S.S. was previously supported by a Doctoral Research Award from the Canadian Prostate Cancer Research Initiative/Canadian Institutes of Health Research, and is currently supported by the Fund for Research and Progress in Urology, Johns Hopkins Medical Institutions.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/5
Y1 - 2007/5
N2 - The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.
AB - The epidemiologic literature on sexually transmitted infections, clinical prostatitis, prostatic calculi, polymorphisms in immune response genes, and nonsteroidal antiinflammatory drug use as potential sources and modifiers of intraprostatic inflammation is reviewed in relation to prostate cancer. Particular emphasis is placed on study methodology and its influence on study findings. Although evidence from reviewed epidemiologic studies, together with laboratory and clinical studies, is suggestive of a role for prostatic inflammation in the etiology of prostate cancer, additional large, prospective studies are necessary to address methodological limitations of existing studies, and to investigate a broader range of potential sources of intraprostatic inflammation.
KW - Epidemiology
KW - Immune response
KW - Inflammation
KW - Nonsteroidal antiinflammatory drugs
KW - Prostate cancer
KW - Prostatitis
KW - Sexually transmitted infections
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U2 - 10.1016/j.urolonc.2006.09.014
DO - 10.1016/j.urolonc.2006.09.014
M3 - Review article
C2 - 17483023
AN - SCOPUS:34247579199
SN - 1078-1439
VL - 25
SP - 242
EP - 249
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
IS - 3
ER -