Inflammation in sleep apnea: An update

Dileep Unnikrishnan, Jonathan Jun, Vsevolod Polotsky

Research output: Contribution to journalReview article

Abstract

Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the premise that obesity is a pro-inflammatory state, and that physiological derangements during sleep in subjects with OSA further aggravate inflammation. In support of this theory, some clinical studies have shown elevated inflammatory biomarkers in OSA subjects, or improvement in these markers following treatment of OSA. However, the data are inconsistent and often confounded by the effects of comorbid obesity. Animal models of OSA have been developed, which involve exposure of rodents or cells to intermittent hypoxia, a hallmark feature of OSA. Several of these experiments demonstrate that intermittent hypoxia can stimulate inflammatory pathways and lead to cardiovascular or metabolic pathology. In this review, we review relationships between OSA and inflammation, with particular attention to studies published within the last year.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalReviews in Endocrine and Metabolic Disorders
Volume16
Issue number1
DOIs
StatePublished - Mar 1 2015

Keywords

  • Hypoxia
  • Inflammation
  • Metabolism
  • Sleep apnea

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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