Inflammation in prostate carcinogenesis

Angelo M. De Marzo, Elizabeth A. Platz, Siobhan Sutcliffe, Jianfeng Xu, Henrik Grönberg, Charles G. Drake, Yasutomo Nakai, William B. Isaacs, William G. Nelson

Research output: Contribution to journalReview articlepeer-review

Abstract

About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.

Original languageEnglish (US)
Pages (from-to)256-269
Number of pages14
JournalNature Reviews Cancer
Volume7
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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