Inflammation in prostate carcinogenesis

Angelo M. De Marzo; Elizabeth A. Platz; Siobhan Sutcliffe; Jianfeng Xu; Henrik Grönberg; Charles G. Drake; Yasutomo Nakai; William B. Isaacs; William G. Nelson

doi:10.1038/nrc2090

Inflammation in prostate carcinogenesis

Angelo M. De Marzo, Elizabeth A. Platz, Siobhan Sutcliffe, Jianfeng Xu, Henrik Grönberg, Charles G. Drake, Yasutomo Nakai, William B. Isaacs, William G. Nelson

Research output: Contribution to journal › Review article › peer-review

1104 Scopus citations

Abstract

About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.

Original language	English (US)
Pages (from-to)	256-269
Number of pages	14
Journal	Nature Reviews Cancer
Volume	7
Issue number	4
DOIs	https://doi.org/10.1038/nrc2090
State	Published - Apr 2007

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc2090

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@article{870394f0036b46c9af1787a35556808f,

title = "Inflammation in prostate carcinogenesis",

abstract = "About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.",

author = "{De Marzo}, {Angelo M.} and Platz, {Elizabeth A.} and Siobhan Sutcliffe and Jianfeng Xu and Henrik Gr{\"o}nberg and Drake, {Charles G.} and Yasutomo Nakai and Isaacs, {William B.} and Nelson, {William G.}",

note = "Funding Information: The authors would like to thank Amelia K. Thomas for sketching the early concept designs for figure 2. Support was received from the Department of Defense Congressional Dir. Med.Research Program; The Public Health Services National Institutes of Health (NIH) and the National Cancer Institute, NIH and National Cancer Institute Specialized Programs of Research Excellencein Prostate Cancer, and philanthropicsup-port from the Donald and Susan Sturm Foundation, B. L. Schwartz and R. A. Barry. A.M.D. is a Helen and Peter Bing Scholar through The Patrick C. Walsh Prostate Cancer Research Fund.",

year = "2007",

month = apr,

doi = "10.1038/nrc2090",

language = "English (US)",

volume = "7",

pages = "256--269",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "4",

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TY - JOUR

T1 - Inflammation in prostate carcinogenesis

AU - De Marzo, Angelo M.

AU - Platz, Elizabeth A.

AU - Sutcliffe, Siobhan

AU - Xu, Jianfeng

AU - Grönberg, Henrik

AU - Drake, Charles G.

AU - Nakai, Yasutomo

AU - Isaacs, William B.

AU - Nelson, William G.

N1 - Funding Information: The authors would like to thank Amelia K. Thomas for sketching the early concept designs for figure 2. Support was received from the Department of Defense Congressional Dir. Med.Research Program; The Public Health Services National Institutes of Health (NIH) and the National Cancer Institute, NIH and National Cancer Institute Specialized Programs of Research Excellencein Prostate Cancer, and philanthropicsup-port from the Donald and Susan Sturm Foundation, B. L. Schwartz and R. A. Barry. A.M.D. is a Helen and Peter Bing Scholar through The Patrick C. Walsh Prostate Cancer Research Fund.

PY - 2007/4

Y1 - 2007/4

N2 - About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.

AB - About 20% of all human cancers are caused by chronic infection or chronic inflammatory states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes that exposure to environmental factors such as infectious agents and dietary carcinogens, and hormonal imbalances lead to injury of the prostate and to the development of chronic inflammation and regenerative 'risk factor' lesions, referred to as proliferative inflammatory atrophy (PIA). By developing new experimental animal models coupled with classical epidemiological studies, genetic epidemiological studies and molecular pathological approaches, we should be able to determine whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease.

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DO - 10.1038/nrc2090

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VL - 7

SP - 256

EP - 269

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 4

ER -

Inflammation in prostate carcinogenesis

Abstract

ASJC Scopus subject areas

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