Inflammation, Immunity, and Oxidative Stress in Hypertension—Partners in Crime?

Ian R. Barrows, Ali Ramezani, Dominic S. Raj

Research output: Contribution to journalReview articlepeer-review

Abstract

Hypertension is considered as the most common risk factor for cardiovascular disease. Inflammatory processes link hypertension and cardiovascular disease, and participate in their pathophysiology. In recent years, there has been an increase in research focused on unraveling the role of inflammation and immune activation in development and maintenance of hypertension. Although inflammation is known to be associated with hypertension, whether inflammation is a cause or effect of hypertension remains to be elucidated. This review describes the recent studies that link inflammation and hypertension and demonstrate the involvement of oxidative stress and endothelial dysfunction—two of the key processes in the development of hypertension. Etiology of hypertension, including novel immune cell subtypes, cytokines, toll-like receptors, inflammasomes, and gut microbiome, found to be associated with inflammation and hypertension are summarized and discussed. Most recent findings in this field are presented with special emphasis on potential of anti-inflammatory drugs and statins for treatment of hypertension.

Original languageEnglish (US)
Pages (from-to)122-130
Number of pages9
JournalAdvances in Chronic Kidney Disease
Volume26
Issue number2
DOIs
StatePublished - Mar 2019

Keywords

  • Anti-inflammatory drugs
  • Hypertension
  • Immune activation
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Nephrology

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