Inflammation, Depression, and Slow Gait: A High Mortality Phenotype in Later Life

Patrick J. Brown, Steven P. Roose, Jun Zhang, Melanie Wall, Bret R. Rutherford, Hilsa N. Ayonayon, Meryl A. Butters, Tamara Harris, Anne B. Newman, Suzanne Satterfield, Eleanor Marie Simonsick, Kristine Yaffe

Research output: Contribution to journalArticle

Abstract

Background. Inflammation, slow gait, and depression individually are associated with mortality, yet little is known about the trajectories of these measures, their interrelationships, or their collective impact on mortality. Methods. Longitudinal latent class analysis was used to evaluate trajectories of depression (Center for Epidemiologic Studies Depression ≥ 10), slow gait ( 3.2 pg/mL) using data from the Health Aging and Body Composition Study. Logistic regression was used to identify their associations with mortality. Results. For each outcome, low-probability (n inflammation = 1,656, n slow gait = 1,471, n depression = 1,458), increasing-probability (n inflammation = 847, n slow gait = 880, n depression = 1,062), and consistently high-probability (n inflammation = 572, n slow gait = 724, n depression = 555) trajectories were identified, with 22% of all participants classified as having increasing or consistently high-probability trajectories on inflammation, slow gait, and depression (meaning probability of impairment on each outcome increased from low to moderate/high or remained high over 10 years). Trajectories of slow gait were associated with inflammation (r =. 40, p

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume71
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Gait
Inflammation
Phenotype
Mortality
Body Composition
Epidemiologic Studies
Logistic Models
Health

Keywords

  • Depression
  • Frailty
  • Inflammation
  • Mortality
  • Slow Gait

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Inflammation, Depression, and Slow Gait : A High Mortality Phenotype in Later Life. / Brown, Patrick J.; Roose, Steven P.; Zhang, Jun; Wall, Melanie; Rutherford, Bret R.; Ayonayon, Hilsa N.; Butters, Meryl A.; Harris, Tamara; Newman, Anne B.; Satterfield, Suzanne; Simonsick, Eleanor Marie; Yaffe, Kristine.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 71, No. 2, 01.02.2016, p. 221-227.

Research output: Contribution to journalArticle

Brown, PJ, Roose, SP, Zhang, J, Wall, M, Rutherford, BR, Ayonayon, HN, Butters, MA, Harris, T, Newman, AB, Satterfield, S, Simonsick, EM & Yaffe, K 2016, 'Inflammation, Depression, and Slow Gait: A High Mortality Phenotype in Later Life', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 71, no. 2, pp. 221-227. https://doi.org/10.1093/gerona/glv156
Brown, Patrick J. ; Roose, Steven P. ; Zhang, Jun ; Wall, Melanie ; Rutherford, Bret R. ; Ayonayon, Hilsa N. ; Butters, Meryl A. ; Harris, Tamara ; Newman, Anne B. ; Satterfield, Suzanne ; Simonsick, Eleanor Marie ; Yaffe, Kristine. / Inflammation, Depression, and Slow Gait : A High Mortality Phenotype in Later Life. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2016 ; Vol. 71, No. 2. pp. 221-227.
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