Inflammation as a target in prostate cancer

Marshall Scott Lucia, James R. Lambert, Elizabeth A. Platz, Angelo M. De Marzo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epidemiological studies have implicated chronic infections and inflammation as major risk factors for a variety of human cancers. Emerging evidence suggests that chronic inflammation is important for the development of prostate cancer and foci of inflammation (i.e., lymphocytes and macrophages) and is extremely common in the prostate. Multiple mechanisms have been investigated in studies examining the role of inflammation in prostate cancer initiation and development. In this chapter, we review the current state of thinking on the causes of prostatic inflammation, inflammatory genes potentially involved in prostatic inflammation and carcinogenesis, and the role of inflammation in the development of prostate cancer. An understanding of the role of chronic inflammation in the development of prostate cancer will provide new therapeutic strategies to combat the disease.

Original languageEnglish (US)
Title of host publicationDrug Management of Prostate Cancer
PublisherSpringer New York
Pages375-386
Number of pages12
ISBN (Print)9781603278317
DOIs
StatePublished - 2010

Keywords

  • Carcinogenesis
  • Chemoprevention
  • Chemotherapy
  • Cytokines
  • Inflammation
  • Oxidative stress
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine(all)

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