Inflammation and sickle cell anemia

Camila Bononi de Almeida, Gregory J. Kato, Nicola Conran

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inflammatory processes play a key role in the initiation of the acute painful vaso-occlusive crises that constitute the main cause of hospitalization in individuals with sickle cell anemia, as well as many of its numerous complications, including autosplenectomy, pulmonary hypertension, acute chest syndrome, leg ulcers, nephropathy and stroke. Ischemia-reperfusion injury (due to microvascular and macrovascular occlusions), membrane alterations of the sickle red blood cell, and hemolysis may all trigger endogenous proinflammatory signals (damage-associated molecular patterns-DAMPs) that lead to the vicious circle of pan-cellular activation, inflammatory mediator release, leukocyte recruitment and occlusive mechanisms that result in the chronic inflammatory state that is associated with sickle cell anemia. We, herein, review the probable primary inflammatory triggers that initiate inflammatory mechanisms in the disease and postulate the cells and molecules that may contribute to establish chronic inflammation. The anti-inflammatory effects of hydroxyurea are discussed, as are novel anti-inflammatory approaches currently under study.

Original languageEnglish (US)
Title of host publicationSickle Cell Anemia: From Basic Science to Clinical Practice
PublisherSpringer International Publishing
Pages177-212
Number of pages36
ISBN (Electronic)9783319067131
ISBN (Print)9783319067124
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Keywords

  • Cytokine
  • DAMPs
  • Endothelium
  • Ischemia-reperfusion
  • Leukocytes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

de Almeida, C. B., Kato, G. J., & Conran, N. (2016). Inflammation and sickle cell anemia. In Sickle Cell Anemia: From Basic Science to Clinical Practice (pp. 177-212). Springer International Publishing. https://doi.org/10.1007/978-3-319-06713-1_8