Inflammation and immunity in schizophrenia

Implications for pathophysiology and treatment

Golam M. Khandaker, Lesley Cousins, Julia Deakin, Belinda R. Lennox, Robert H Yolken, Peter B. Jones

Research output: Contribution to journalArticle

Abstract

Complex interactions between the immune system and the brain might have important aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible association between schizophrenia and the immune system was postulated over a century ago, and is supported by epidemiological and genetic studies pointing to links with infection and inflammation. Contrary to the traditional view that the brain is an immunologically privileged site shielded behind the blood-brain barrier, studies in the past 20 years have noted complex interactions between the immune system, systemic inflammation, and the brain, which can lead to changes in mood, cognition, and behaviour. In this Review, we describe some of the important areas of research regarding innate and adaptive immune response in schizophrenia and related psychotic disorders that, we think, will be of interest to psychiatric clinicians and researchers. We discuss potential mechanisms and therapeutic implications of these findings, including studies of anti-inflammatory drugs in schizophrenia, describe areas for development, and offer testable hypotheses for future investigations.

Original languageEnglish (US)
Pages (from-to)258-270
Number of pages13
JournalThe Lancet Psychiatry
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Immune System
Immunity
Schizophrenia
Inflammation
Brain
Brain Diseases
Adaptive Immunity
Encephalitis
Blood-Brain Barrier
Innate Immunity
Psychotic Disorders
Cognition
Psychiatry
Epidemiologic Studies
Anti-Inflammatory Agents
Research Personnel
Therapeutics
Infection
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Inflammation and immunity in schizophrenia : Implications for pathophysiology and treatment. / Khandaker, Golam M.; Cousins, Lesley; Deakin, Julia; Lennox, Belinda R.; Yolken, Robert H; Jones, Peter B.

In: The Lancet Psychiatry, Vol. 2, No. 3, 01.03.2015, p. 258-270.

Research output: Contribution to journalArticle

Khandaker, Golam M. ; Cousins, Lesley ; Deakin, Julia ; Lennox, Belinda R. ; Yolken, Robert H ; Jones, Peter B. / Inflammation and immunity in schizophrenia : Implications for pathophysiology and treatment. In: The Lancet Psychiatry. 2015 ; Vol. 2, No. 3. pp. 258-270.
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