Inflammation and HIV Transmission in Sub-Saharan Africa

Rupert Kaul, Jessica Prodger, Vineet Joag, Brett Shannon, Sergey Yegorov, Ronald Galiwango, Lyle McKinnon

Research output: Contribution to journalReview article

Abstract

While the per-contact risk of sexual HIV transmission is relatively low, it is fourfold higher in sub-Saharan Africa, and this may partly explain the major global disparities that exist in HIV prevalence. Genital immune parameters are key determinants of HIV transmission risk, including epithelial integrity and the presence of highly HIV-susceptible intraepithelial or submucosal CD4+ T cell target cells. Biological parameters that may enhance mucosal HIV susceptibility in highly HIV-affected regions of sub-Saharan Africa include increased levels of mucosal inflammation, which can affect both epithelial integrity and target cell availability, as well as the increased mucosal surface area that is afforded by an intact foreskin, contraceptive choices, and intravaginal practices. There are multifactorial causes for increased mucosal inflammation, with the prevalence and nature of common co-infections being particularly relevant.

Original languageEnglish (US)
Pages (from-to)216-222
Number of pages7
JournalCurrent HIV/AIDS reports
Volume12
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • Co-infections
  • HIV transmission
  • Inflammation
  • Mucosal immunology
  • Sub-Saharan Africa

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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  • Cite this

    Kaul, R., Prodger, J., Joag, V., Shannon, B., Yegorov, S., Galiwango, R., & McKinnon, L. (2015). Inflammation and HIV Transmission in Sub-Saharan Africa. Current HIV/AIDS reports, 12(2), 216-222. https://doi.org/10.1007/s11904-015-0269-5