TY - JOUR
T1 - Inflamm-aging does not simply reflect increases in pro-inflammatory markers
AU - Morrisette-Thomas, Vincent
AU - Cohen, Alan A.
AU - Fülöp, Tamàs
AU - Riesco, Éléonor
AU - Legault, Véronique
AU - Li, Qing
AU - Milot, Emmanuel
AU - Dusseault-Bélanger, Françis
AU - Ferrucci, Luigi
PY - 2014
Y1 - 2014
N2 - Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by pro-inflammatory biomarkers. However, most studies use just one marker at a time, sometimes leading to conflicting results due to complex interactions among the markers. A multidimensional approach allows a more robust interpretation of the various relationships between the markers. We applied principal component analysis (PCA) to 19 inflammatory biomarkers from the InCHIANTI study. We identified a clear, stable structure among the markers, with the first axis explaining inflammatory activation (both pro- and anti-inflammatory markers loaded strongly and positively) and the second axis innate immune response. The first but not the second axis was strongly correlated with age (r= 0.56, p
AB - Many biodemographic studies use biomarkers of inflammation to understand or predict chronic disease and aging. Inflamm-aging, i.e. chronic low-grade inflammation during aging, is commonly characterized by pro-inflammatory biomarkers. However, most studies use just one marker at a time, sometimes leading to conflicting results due to complex interactions among the markers. A multidimensional approach allows a more robust interpretation of the various relationships between the markers. We applied principal component analysis (PCA) to 19 inflammatory biomarkers from the InCHIANTI study. We identified a clear, stable structure among the markers, with the first axis explaining inflammatory activation (both pro- and anti-inflammatory markers loaded strongly and positively) and the second axis innate immune response. The first but not the second axis was strongly correlated with age (r= 0.56, p
KW - Aging
KW - Biomarker
KW - Chronic disease
KW - Inflammation
KW - Multivariate
UR - http://www.scopus.com/inward/record.url?scp=84904746130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904746130&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2014.06.005
DO - 10.1016/j.mad.2014.06.005
M3 - Article
C2 - 25011077
AN - SCOPUS:84904746130
SN - 0047-6374
VL - 139
SP - 49
EP - 57
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 1
ER -