Abstract
Methods: Retrospective review of infectious complications in all IP receiving solid organ and bone marrow transplants from 1984-1996 at-one large referral center. Results: 43/2541 recipients (1.6%) were IP: 21 renal, 10 bone marrow (2 allogeneic, 8 autologous), 8 heart, 4 liver. Areas of origin were Turkey (10), Japan (7), Middle East (7), South/Latin America (12), Eastern Europe (4), and the Caribbean (3). Mean follow-up was 16.9 mos. Pre-transplant screen showed 6/15 + PPD, 6733 HbsAg+, 0/8 stool ova and parasites. Renal Bone Marrow Heart Liver Total # pts with inf. 8 (38%) 7 (70%) 2 (25%) 3 (75%) 20 (47%) Bacterernia 0 2 0 2 4 Sepsis syndrome 0 2 0 2 4 UTI 4 1 0 0 5 Pneumonia 0 2 0 1 3 Endocarditis 0 0 0 1 1 Peritonitis 0 0 0 1 1 C. difficile 0 2 0 0 2 CMV 4 1 0 1 6 HSV/VZV 0/0 2/2 0/1 1/0 3/3 Fungal 1 3 0 2 6 TB 1 0 0 0 1 HBV/HCV 1/1 0/0 I/O 1/0 3/1 Deaths 3 (1 ID) 2 0 2 7(16.3%) Conclusions: IP's can be safely transplanted despite clinical concern for reactivation of endemic infections such as TB, hepatitis B and C, and strongyloidiasis. Appropriate screening and prophylaxis are crucial. Liver and bone marrow IP recipients appear to be at increased risk relative to other organ recipients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 484 |
| Number of pages | 1 |
| Journal | Clinical Infectious Diseases |
| Volume | 25 |
| Issue number | 2 |
| State | Published - 1997 |
| Externally published | Yes |
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases