Infectious outcomes in transplantation in international patients (IP)

R. Avery, J. Brakeman, K. Adal, J. M. Henderson, B. Bolwell, D. Longworth

Research output: Contribution to journalArticlepeer-review

Abstract

Methods: Retrospective review of infectious complications in all IP receiving solid organ and bone marrow transplants from 1984-1996 at-one large referral center. Results: 43/2541 recipients (1.6%) were IP: 21 renal, 10 bone marrow (2 allogeneic, 8 autologous), 8 heart, 4 liver. Areas of origin were Turkey (10), Japan (7), Middle East (7), South/Latin America (12), Eastern Europe (4), and the Caribbean (3). Mean follow-up was 16.9 mos. Pre-transplant screen showed 6/15 + PPD, 6733 HbsAg+, 0/8 stool ova and parasites. Renal Bone Marrow Heart Liver Total # pts with inf. 8 (38%) 7 (70%) 2 (25%) 3 (75%) 20 (47%) Bacterernia 0 2 0 2 4 Sepsis syndrome 0 2 0 2 4 UTI 4 1 0 0 5 Pneumonia 0 2 0 1 3 Endocarditis 0 0 0 1 1 Peritonitis 0 0 0 1 1 C. difficile 0 2 0 0 2 CMV 4 1 0 1 6 HSV/VZV 0/0 2/2 0/1 1/0 3/3 Fungal 1 3 0 2 6 TB 1 0 0 0 1 HBV/HCV 1/1 0/0 I/O 1/0 3/1 Deaths 3 (1 ID) 2 0 2 7(16.3%) Conclusions: IP's can be safely transplanted despite clinical concern for reactivation of endemic infections such as TB, hepatitis B and C, and strongyloidiasis. Appropriate screening and prophylaxis are crucial. Liver and bone marrow IP recipients appear to be at increased risk relative to other organ recipients.

Original languageEnglish (US)
Number of pages1
JournalClinical Infectious Diseases
Volume25
Issue number2
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Infectious outcomes in transplantation in international patients (IP)'. Together they form a unique fingerprint.

Cite this