Infectious mimics of inflammatory bowel disease

Feriyl Bhaijee, Christina Arnold, Dora Lam-Himlin, Elizabeth A Montgomery, Lysandra Voltaggio

Research output: Contribution to journalArticle

Abstract

Given the considerable overlap between the clinical, endoscopic, and histologic features of infectious colitides and inflammatory bowel disease (IBD), correct classification of chronic colitis requires thorough clinical and pathologic evaluation of affected patients. Herein, we discuss a pattern-based approach to colitis, classification of IBD, and infectious mimics of IBD. Infectious mimics of IBD include bacterial pathogens (. Shigella, Campylobacter, Salmonella, shiga toxin-producing Escherichia coli, Yersinia, Aeromonas), tuberculous and non-tuberculous mycobacterial infections, sexually transmitted proctocolitis (syphilis, lymphogranuloma venereum), amoebiasis, and the recently described cord colitis syndrome. The histologic finding of chronic active colitis should be considered infectious until proven otherwise in order to detect treatable, curable conditions and prevent exacerbation by inappropriate immunomodulatory therapy. Family and medical histories, signs and symptoms, radiologic and endoscopic features (especially disease distribution), and serologic/ancillary studies for markers of infection are invaluable tools that aid in the distinction between infectious colitis and IBD.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalDiagnostic Histopathology
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2015

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Colitis
Inflammatory Bowel Diseases
Medical History Taking
Lymphogranuloma Venereum
Proctocolitis
Shiga-Toxigenic Escherichia coli
Aeromonas
Yersinia
Amebiasis
Shigella
Campylobacter
Immunomodulation
Syphilis
Sexually Transmitted Diseases
Salmonella
Signs and Symptoms
Infection

Keywords

  • Crohn
  • Histopathology
  • Infection
  • Inflammatory bowel disease
  • Mimics
  • Ulcerative colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Infectious mimics of inflammatory bowel disease. / Bhaijee, Feriyl; Arnold, Christina; Lam-Himlin, Dora; Montgomery, Elizabeth A; Voltaggio, Lysandra.

In: Diagnostic Histopathology, Vol. 21, No. 7, 01.07.2015, p. 267-275.

Research output: Contribution to journalArticle

Bhaijee, Feriyl ; Arnold, Christina ; Lam-Himlin, Dora ; Montgomery, Elizabeth A ; Voltaggio, Lysandra. / Infectious mimics of inflammatory bowel disease. In: Diagnostic Histopathology. 2015 ; Vol. 21, No. 7. pp. 267-275.
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