Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency

Viviane C. Campos, Mônica R. Barrios, Roberto Salvatori, Roque Pacheco de Almeida, Enaldo V. de Melo, Ana C S Nascimento, Amélia Ribeiro de Jesus, Manuel H. Aguiar-Oliveira

Research output: Contribution to journalArticle

Abstract

Growth hormone is important for the development and function of the immune system, but there is controversy on whether growth hormone deficiency is associated to immune disorders. A model of isolated growth hormone deficiency may clarify if the lack of growth hormone is associated with increased susceptibility to infections, or with an altered responsiveness of the immune system. We have studied the frequency of infectious diseases and the immune function in adults with congenital, untreated isolated growth hormone deficiency. In a cross-sectional study, 35 adults with isolated growth hormone deficiency due to a homozygous mutation in the growth hormone releasing hormone receptor gene and 31 controls were submitted to a clinical questionnaire, physical examination serology for tripanosomiasis, leishmaniasis, HIV, tetanus, hepatitis B and C, and serum total immunoglobulin G, M, E and A measurement. The immune response was evaluated in a subset of these subjects by skin tests and response to vaccination for hepatitis B, tetanus, and bacillus Calmette-Guérin. There was no difference between the groups in history of infectious diseases and baseline serology. Isolated growth hormone deficiency subjects had lower total IgG, but within normal range. There was no difference in the response to any of the vaccinations or in the positivity to protein Purified Derived, streptokinase or candidin. Adult untreated isolated growth hormone deficiency does not cause an increased frequency of infectious diseases, and does not alter serologic tests, but is associated with lower total IgG levels, without detectable clinical impact.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalEndocrine
DOIs
StateAccepted/In press - Aug 3 2016

Fingerprint

Pituitary Dwarfism
Communicable Diseases
Growth Hormone
Immunoglobulin G
Tetanus
Serology
Hepatitis B
Immune System
Vaccination
Streptokinase
Leishmaniasis
Immune System Diseases
Serologic Tests
Hepatitis C
Skin Tests
Immunoglobulin A
Bacillus
Physical Examination
Immunoglobulin M
Reference Values

Keywords

  • Cellular and humoral immune response
  • Infectious diseases
  • Isolated GH deficiency
  • Vaccines and skin tests

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Campos, V. C., Barrios, M. R., Salvatori, R., de Almeida, R. P., de Melo, E. V., Nascimento, A. C. S., ... Aguiar-Oliveira, M. H. (Accepted/In press). Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency. Endocrine, 1-9. https://doi.org/10.1007/s12020-016-1061-z

Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency. / Campos, Viviane C.; Barrios, Mônica R.; Salvatori, Roberto; de Almeida, Roque Pacheco; de Melo, Enaldo V.; Nascimento, Ana C S; de Jesus, Amélia Ribeiro; Aguiar-Oliveira, Manuel H.

In: Endocrine, 03.08.2016, p. 1-9.

Research output: Contribution to journalArticle

Campos, VC, Barrios, MR, Salvatori, R, de Almeida, RP, de Melo, EV, Nascimento, ACS, de Jesus, AR & Aguiar-Oliveira, MH 2016, 'Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency', Endocrine, pp. 1-9. https://doi.org/10.1007/s12020-016-1061-z
Campos, Viviane C. ; Barrios, Mônica R. ; Salvatori, Roberto ; de Almeida, Roque Pacheco ; de Melo, Enaldo V. ; Nascimento, Ana C S ; de Jesus, Amélia Ribeiro ; Aguiar-Oliveira, Manuel H. / Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency. In: Endocrine. 2016 ; pp. 1-9.
@article{7f919a4675d94bd485b71396be8e7c9c,
title = "Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency",
abstract = "Growth hormone is important for the development and function of the immune system, but there is controversy on whether growth hormone deficiency is associated to immune disorders. A model of isolated growth hormone deficiency may clarify if the lack of growth hormone is associated with increased susceptibility to infections, or with an altered responsiveness of the immune system. We have studied the frequency of infectious diseases and the immune function in adults with congenital, untreated isolated growth hormone deficiency. In a cross-sectional study, 35 adults with isolated growth hormone deficiency due to a homozygous mutation in the growth hormone releasing hormone receptor gene and 31 controls were submitted to a clinical questionnaire, physical examination serology for tripanosomiasis, leishmaniasis, HIV, tetanus, hepatitis B and C, and serum total immunoglobulin G, M, E and A measurement. The immune response was evaluated in a subset of these subjects by skin tests and response to vaccination for hepatitis B, tetanus, and bacillus Calmette-Gu{\'e}rin. There was no difference between the groups in history of infectious diseases and baseline serology. Isolated growth hormone deficiency subjects had lower total IgG, but within normal range. There was no difference in the response to any of the vaccinations or in the positivity to protein Purified Derived, streptokinase or candidin. Adult untreated isolated growth hormone deficiency does not cause an increased frequency of infectious diseases, and does not alter serologic tests, but is associated with lower total IgG levels, without detectable clinical impact.",
keywords = "Cellular and humoral immune response, Infectious diseases, Isolated GH deficiency, Vaccines and skin tests",
author = "Campos, {Viviane C.} and Barrios, {M{\^o}nica R.} and Roberto Salvatori and {de Almeida}, {Roque Pacheco} and {de Melo}, {Enaldo V.} and Nascimento, {Ana C S} and {de Jesus}, {Am{\'e}lia Ribeiro} and Aguiar-Oliveira, {Manuel H.}",
year = "2016",
month = "8",
day = "3",
doi = "10.1007/s12020-016-1061-z",
language = "English (US)",
pages = "1--9",
journal = "Endocrine",
issn = "1355-008X",
publisher = "Humana Press",

}

TY - JOUR

T1 - Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency

AU - Campos, Viviane C.

AU - Barrios, Mônica R.

AU - Salvatori, Roberto

AU - de Almeida, Roque Pacheco

AU - de Melo, Enaldo V.

AU - Nascimento, Ana C S

AU - de Jesus, Amélia Ribeiro

AU - Aguiar-Oliveira, Manuel H.

PY - 2016/8/3

Y1 - 2016/8/3

N2 - Growth hormone is important for the development and function of the immune system, but there is controversy on whether growth hormone deficiency is associated to immune disorders. A model of isolated growth hormone deficiency may clarify if the lack of growth hormone is associated with increased susceptibility to infections, or with an altered responsiveness of the immune system. We have studied the frequency of infectious diseases and the immune function in adults with congenital, untreated isolated growth hormone deficiency. In a cross-sectional study, 35 adults with isolated growth hormone deficiency due to a homozygous mutation in the growth hormone releasing hormone receptor gene and 31 controls were submitted to a clinical questionnaire, physical examination serology for tripanosomiasis, leishmaniasis, HIV, tetanus, hepatitis B and C, and serum total immunoglobulin G, M, E and A measurement. The immune response was evaluated in a subset of these subjects by skin tests and response to vaccination for hepatitis B, tetanus, and bacillus Calmette-Guérin. There was no difference between the groups in history of infectious diseases and baseline serology. Isolated growth hormone deficiency subjects had lower total IgG, but within normal range. There was no difference in the response to any of the vaccinations or in the positivity to protein Purified Derived, streptokinase or candidin. Adult untreated isolated growth hormone deficiency does not cause an increased frequency of infectious diseases, and does not alter serologic tests, but is associated with lower total IgG levels, without detectable clinical impact.

AB - Growth hormone is important for the development and function of the immune system, but there is controversy on whether growth hormone deficiency is associated to immune disorders. A model of isolated growth hormone deficiency may clarify if the lack of growth hormone is associated with increased susceptibility to infections, or with an altered responsiveness of the immune system. We have studied the frequency of infectious diseases and the immune function in adults with congenital, untreated isolated growth hormone deficiency. In a cross-sectional study, 35 adults with isolated growth hormone deficiency due to a homozygous mutation in the growth hormone releasing hormone receptor gene and 31 controls were submitted to a clinical questionnaire, physical examination serology for tripanosomiasis, leishmaniasis, HIV, tetanus, hepatitis B and C, and serum total immunoglobulin G, M, E and A measurement. The immune response was evaluated in a subset of these subjects by skin tests and response to vaccination for hepatitis B, tetanus, and bacillus Calmette-Guérin. There was no difference between the groups in history of infectious diseases and baseline serology. Isolated growth hormone deficiency subjects had lower total IgG, but within normal range. There was no difference in the response to any of the vaccinations or in the positivity to protein Purified Derived, streptokinase or candidin. Adult untreated isolated growth hormone deficiency does not cause an increased frequency of infectious diseases, and does not alter serologic tests, but is associated with lower total IgG levels, without detectable clinical impact.

KW - Cellular and humoral immune response

KW - Infectious diseases

KW - Isolated GH deficiency

KW - Vaccines and skin tests

UR - http://www.scopus.com/inward/record.url?scp=84982845040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982845040&partnerID=8YFLogxK

U2 - 10.1007/s12020-016-1061-z

DO - 10.1007/s12020-016-1061-z

M3 - Article

C2 - 27484773

AN - SCOPUS:84982845040

SP - 1

EP - 9

JO - Endocrine

JF - Endocrine

SN - 1355-008X

ER -