Infection with parasitic nematodes confounds vaccination efficacy

Joseph F. Urban, Nina R. Steenhard, Gloria I. Solano-Aguilar, Harry D. Dawson, Onyinye I. Iweala, Cathryn R. Nagler, Gregory S. Noland, Nirbhay Kumar, Robert M. Anthony, Terez Shea-Donohue, Joel Weinstock, William C. Gause

Research output: Contribution to journalArticle

Abstract

T helper (Th) cells produce signature cytokine patterns, induced largely by intracellular versus extracellular pathogens that provide the cellular and molecular basis for counter regulatory expression of protective immunity during concurrent infections. The production of IL-12 and IFN-γ, for example, resulting from exposure to many bacterial, viral, and protozoan pathogens is responsible for Th1-derived protective responses that also can inhibit development of Th2-cells expressing IL-4-dependent immunity to extracellular helminth parasites and vice versa. In a similar manner, concurrent helminth infection alters optimal vaccine-induced responses in humans and livestock; however, the consequences of this condition have not been adequately studied especially in the context of a challenge infection following vaccination. Demands for new and effective vaccines to control chronic and emerging diseases, and the need for rapid deployment of vaccines for bio security concerns requires a systematic evaluation of confounding factors that limit vaccine efficacy. One common albeit overlooked confounder is the presence of gastrointestinal nematode parasites in populations of humans and livestock targeted for vaccination. This is particularly important in areas of the world were helminth infections are prevalent, but the interplay between parasites and emerging diseases that can be transmitted worldwide make this a global issue. In addition, it is not clear if the epidemic in allergic disease in industrialized countries substitutes for geohelminth infection to interfere with effective vaccination regimens. This presentation will focus on recent vaccination studies in mice experimentally infected with Heligmosomoides polygyrus to model the condition of gastrointestinal parasite infestation in mammalian populations targeted for vaccination. In addition, a large animal vaccination and challenge model against Mycoplasma hyopneumonia in swine exposed to Ascaris suum will provide a specific example of the need for further work in this area, and for controlled field studies to assess the impact of other similar scenarios.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalVeterinary Parasitology
Volume148
Issue number1 SPEC. ISS.
DOIs
StatePublished - Aug 19 2007

Fingerprint

animal parasitic nematodes
Parasitic Diseases
Vaccination
vaccination
Helminths
Parasites
Vaccines
infection
vaccines
helminthiasis
parasites
Infection
emerging diseases
Livestock
Immunity
livestock
Nematospiroides dubius
immunity
Mycoplasma hyopneumoniae
Heligmosomoides polygyrus

Keywords

  • Cytokine gene expression
  • Immune modulating parasitic infection
  • Protective immunity
  • Th2-associated immunity

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Parasitology
  • veterinary(all)

Cite this

Urban, J. F., Steenhard, N. R., Solano-Aguilar, G. I., Dawson, H. D., Iweala, O. I., Nagler, C. R., ... Gause, W. C. (2007). Infection with parasitic nematodes confounds vaccination efficacy. Veterinary Parasitology, 148(1 SPEC. ISS.), 14-20. https://doi.org/10.1016/j.vetpar.2007.05.006

Infection with parasitic nematodes confounds vaccination efficacy. / Urban, Joseph F.; Steenhard, Nina R.; Solano-Aguilar, Gloria I.; Dawson, Harry D.; Iweala, Onyinye I.; Nagler, Cathryn R.; Noland, Gregory S.; Kumar, Nirbhay; Anthony, Robert M.; Shea-Donohue, Terez; Weinstock, Joel; Gause, William C.

In: Veterinary Parasitology, Vol. 148, No. 1 SPEC. ISS., 19.08.2007, p. 14-20.

Research output: Contribution to journalArticle

Urban, JF, Steenhard, NR, Solano-Aguilar, GI, Dawson, HD, Iweala, OI, Nagler, CR, Noland, GS, Kumar, N, Anthony, RM, Shea-Donohue, T, Weinstock, J & Gause, WC 2007, 'Infection with parasitic nematodes confounds vaccination efficacy', Veterinary Parasitology, vol. 148, no. 1 SPEC. ISS., pp. 14-20. https://doi.org/10.1016/j.vetpar.2007.05.006
Urban JF, Steenhard NR, Solano-Aguilar GI, Dawson HD, Iweala OI, Nagler CR et al. Infection with parasitic nematodes confounds vaccination efficacy. Veterinary Parasitology. 2007 Aug 19;148(1 SPEC. ISS.):14-20. https://doi.org/10.1016/j.vetpar.2007.05.006
Urban, Joseph F. ; Steenhard, Nina R. ; Solano-Aguilar, Gloria I. ; Dawson, Harry D. ; Iweala, Onyinye I. ; Nagler, Cathryn R. ; Noland, Gregory S. ; Kumar, Nirbhay ; Anthony, Robert M. ; Shea-Donohue, Terez ; Weinstock, Joel ; Gause, William C. / Infection with parasitic nematodes confounds vaccination efficacy. In: Veterinary Parasitology. 2007 ; Vol. 148, No. 1 SPEC. ISS. pp. 14-20.
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