Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark

Kyrillos M. Meshreky; Joel Wood; Kodavali V. Chowdari; Martica H. Hall; Kristine A. Wilckens; Robert Yolken; Daniel J. Buysse; Vishwajit L. Nimgaonkar

doi:10.1016/j.psychres.2019.112502

Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark

Kyrillos M. Meshreky, Joel Wood, Kodavali V. Chowdari, Martica H. Hall, Kristine A. Wilckens, Robert Yolken, Daniel J. Buysse, Vishwajit L. Nimgaonkar

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Persistent infection with Herpes Simplex viruses (HSV) and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction. We investigated the association between sleep variables and persistent HSV-1, HSV-2, cytomegalovirus (CMV) and Toxoplasma gondii (Tox) infections. Sleep data were collected from older adults with or without insomnia (N = 311, total); a subset completed polysomnographic and actigraphy studies (N = 145). No significant associations were found between the infections and insomnia or the remaining sleep variables following corrections for multiple comparisons. Sleep dysfunction is unlikely to explain the infection-related cognitive dysfunction.

Original language	English (US)
Article number	112502
Journal	Psychiatry research
Volume	280
DOIs	https://doi.org/10.1016/j.psychres.2019.112502
State	Published - Oct 2019

Keywords

HSV-1
Herpesvirus
Sleep

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2019.112502

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title = "Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark",

abstract = "Persistent infection with Herpes Simplex viruses (HSV) and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction. We investigated the association between sleep variables and persistent HSV-1, HSV-2, cytomegalovirus (CMV) and Toxoplasma gondii (Tox) infections. Sleep data were collected from older adults with or without insomnia (N = 311, total); a subset completed polysomnographic and actigraphy studies (N = 145). No significant associations were found between the infections and insomnia or the remaining sleep variables following corrections for multiple comparisons. Sleep dysfunction is unlikely to explain the infection-related cognitive dysfunction.",

keywords = "HSV-1, Herpesvirus, Sleep",

author = "Meshreky, {Kyrillos M.} and Joel Wood and Chowdari, {Kodavali V.} and Hall, {Martica H.} and Wilckens, {Kristine A.} and Robert Yolken and Buysse, {Daniel J.} and Nimgaonkar, {Vishwajit L.}",

note = "Funding Information: This study was funded in part by grants from the Stanley Medical Research Institute (SMRI, 07R-1712) and the National Institutes of Health (MH63480, TW009114, AG020677). Investigator effort was supported by National Institutes of Health grant AG049879 (KAW). We thank all our research participants. Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = oct,

doi = "10.1016/j.psychres.2019.112502",

language = "English (US)",

volume = "280",

journal = "Psychiatry research",

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T2 - The dog that did not bark

AU - Meshreky, Kyrillos M.

AU - Wood, Joel

AU - Chowdari, Kodavali V.

AU - Hall, Martica H.

AU - Wilckens, Kristine A.

AU - Yolken, Robert

AU - Buysse, Daniel J.

AU - Nimgaonkar, Vishwajit L.

N1 - Funding Information: This study was funded in part by grants from the Stanley Medical Research Institute (SMRI, 07R-1712) and the National Institutes of Health (MH63480, TW009114, AG020677). Investigator effort was supported by National Institutes of Health grant AG049879 (KAW). We thank all our research participants. Publisher Copyright: © 2019

PY - 2019/10

Y1 - 2019/10

N2 - Persistent infection with Herpes Simplex viruses (HSV) and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction. We investigated the association between sleep variables and persistent HSV-1, HSV-2, cytomegalovirus (CMV) and Toxoplasma gondii (Tox) infections. Sleep data were collected from older adults with or without insomnia (N = 311, total); a subset completed polysomnographic and actigraphy studies (N = 145). No significant associations were found between the infections and insomnia or the remaining sleep variables following corrections for multiple comparisons. Sleep dysfunction is unlikely to explain the infection-related cognitive dysfunction.

AB - Persistent infection with Herpes Simplex viruses (HSV) and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction. We investigated the association between sleep variables and persistent HSV-1, HSV-2, cytomegalovirus (CMV) and Toxoplasma gondii (Tox) infections. Sleep data were collected from older adults with or without insomnia (N = 311, total); a subset completed polysomnographic and actigraphy studies (N = 145). No significant associations were found between the infections and insomnia or the remaining sleep variables following corrections for multiple comparisons. Sleep dysfunction is unlikely to explain the infection-related cognitive dysfunction.

KW - HSV-1

KW - Herpesvirus

KW - Sleep

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JO - Psychiatry research

JF - Psychiatry research

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Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark

Abstract

Keywords

ASJC Scopus subject areas

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