Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark

Kyrillos M. Meshreky, Joel Wood, Kodavali V. Chowdari, Martica H. Hall, Kristine A. Wilckens, Robert Yolken, Daniel J. Buysse, Vishwajit L. Nimgaonkar

Research output: Contribution to journalArticlepeer-review


Persistent infection with Herpes Simplex viruses (HSV) and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction. We investigated the association between sleep variables and persistent HSV-1, HSV-2, cytomegalovirus (CMV) and Toxoplasma gondii (Tox) infections. Sleep data were collected from older adults with or without insomnia (N = 311, total); a subset completed polysomnographic and actigraphy studies (N = 145). No significant associations were found between the infections and insomnia or the remaining sleep variables following corrections for multiple comparisons. Sleep dysfunction is unlikely to explain the infection-related cognitive dysfunction.

Original languageEnglish (US)
Article number112502
JournalPsychiatry research
StatePublished - Oct 2019


  • HSV-1
  • Herpesvirus
  • Sleep

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Infection with Herpes Simplex virus type 1 (HSV-1) and sleep: The dog that did not bark'. Together they form a unique fingerprint.

Cite this