TY - JOUR
T1 - Infection with Borna Disease Virus
T2 - Molecular and Immunobiological Characterization of the Agent
AU - Rieht, J. A.
AU - Vande, S.
AU - Zink, M. C.
AU - Clements, J. E.
AU - Herzog, S.
AU - Stitz, L.
AU - Rott, R.
AU - Narayan, O.
N1 - Funding Information:
Received 4 September 1991; revised 20 December 1991. Financial support: This work was supported by grants from Johns Hopkins University and by the Deutsche Forschungsgemeinschaft (Sonderfor-schungsbereich 47, R. 202/7-I). J. A. R. was supported by the Deutsche Forschungsgemeinschaft (Ri 518/1-2). S. V. was supported by the National Institutes of Health (RR00130 and RR07002). Reprints or correspondence: Dr. Opendra Narayan, 720 Rutland Avenue, Traylor G-60, Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
PY - 1992/6
Y1 - 1992/6
N2 - Borna disease virus (BDV), which seems to be distinct from all other known viruses, exhibits a unique mechanism of pathogenesis. This review highlights several aspects of the biology of infection with this virus and summarizes the preliminary characterization of the agent. Studies on BDV may help to illuminate several important areas of neurobiology, including the mechanisms regulating the replication of a new type of RNA virus in the nuclei of neural cells, the neuroinvasiveness and neurotropism of such viruses, their T cell-mediated immunopathology, tolerance in newborn animals to persistent viral infection of the central nervous system, and behavioral diseases and eating disorders induced by such agents.
AB - Borna disease virus (BDV), which seems to be distinct from all other known viruses, exhibits a unique mechanism of pathogenesis. This review highlights several aspects of the biology of infection with this virus and summarizes the preliminary characterization of the agent. Studies on BDV may help to illuminate several important areas of neurobiology, including the mechanisms regulating the replication of a new type of RNA virus in the nuclei of neural cells, the neuroinvasiveness and neurotropism of such viruses, their T cell-mediated immunopathology, tolerance in newborn animals to persistent viral infection of the central nervous system, and behavioral diseases and eating disorders induced by such agents.
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U2 - 10.1093/clinids/14.6.1240
DO - 10.1093/clinids/14.6.1240
M3 - Article
C2 - 1623080
AN - SCOPUS:0026628762
SN - 1058-4838
VL - 14
SP - 1240
EP - 1250
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 6
ER -