Infection or inflammation and ICU seizures

Wendy C. Ziai, Mohammed Rehman

Research output: Chapter in Book/Report/Conference proceedingChapter


Effective treatment of seizures associated with CNS infection and inflammation depends on rapid diagnosis and early attainment of bactericidal activity within the CSF with appropriate antimicrobial agents, or appropriate management of vasculitis-induced cerebral complications. There is nothing specific regarding the management of ICU seizures in these situations, except for a high suspicion by the medical staff, as seizures are not uncommon in this setting. Improvement in long-term neurologic outcome depends on both the therapy of the infectious/inflammatory process and the intensive care multisystem monitoring commonly warranted in this patient population. The primary goal of preserving CNS function is shared by both the neurologist and the intensivist, making a multidisciplinary approach essential.

Original languageEnglish (US)
Title of host publicationSeizures in Critical Care
Subtitle of host publicationA Guide to Diagnosis and Therapeutics
EditorsPanayiotis Varelas
Number of pages73
StatePublished - Dec 1 2010

Publication series

NameCurrent Clinical Neurology
ISSN (Print)1559-0585


  • Central nervous system
  • Encephalitis
  • Infection
  • Inflammation
  • Intensive care unit
  • Lupus
  • Meningitis
  • Seizures

ASJC Scopus subject areas

  • Clinical Neurology


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