@article{3f12094b07b54043846c139a58d1f1de,
title = "Infection and inflammation in schizophrenia and bipolar disorder",
abstract = "The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in soluble CD14, and in BP an increase in C-reactive protein, IgM class antibodies against cytomegalovirus (CMV), and IgG class antibodies against herpes simplex virus 2. Furthermore in BP, we observed a negative relationship between IgG antibodies against CMV and scores for cognitive function.",
keywords = "Antibody level, Bipolar disorder, Inflammation, Neurocognition, Schizophrenia",
author = "Teppei Tanaka and Taro Matsuda and Hayes, {Lindsay N.} and Shuojia Yang and Katrina Rodriguez and Severance, {Emily G.} and Yolken, {Robert H.} and Akira Sawa and Eaton, {William W.}",
note = "Funding Information: This work was supported by the NIH grants [MH-084018 (A.S.), MH-094268 Silvio O. Conte center (A.S., R.H.Y.), MH-069853 (A.S.), MH-085226 (A.S.), MH-088753 (A.S.), MH-092443 (A.S.), MH-105660 (A.S.), and MH-100776) (W.E.), as well as grants from Stanley (A.S., R.H.Y.), S-R/RUSK (A.S.), NARSAD (A.S.), and an anonymous donor to the Department of Mental Health, Bloomberg School of Public Health. We thank Lorraine Brando for critical discussion and Yukiko Lema for formatting assistance. We also thank a fellowship program between the National Center for Neurology and Psychiatry Japan and Johns Hopkins Schizophrenia Center, in particular Dr. Teruhiko Higuchi for support. Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd and Japan Neuroscience Society",
year = "2017",
month = feb,
doi = "10.1016/j.neures.2016.11.002",
language = "English (US)",
volume = "115",
pages = "59--63",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
}