Infection and inflammation in schizophrenia and bipolar disorder

Teppei Tanaka, Taro Matsuda, Lindsay Hayes, Shuojia Yang, Katrina Rodriguez, Emily G Severance, Robert H Yolken, Akira Sawa, William W Eaton

Research output: Contribution to journalArticle

Abstract

The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in soluble CD14, and in BP an increase in C-reactive protein, IgM class antibodies against cytomegalovirus (CMV), and IgG class antibodies against herpes simplex virus 2. Furthermore in BP, we observed a negative relationship between IgG antibodies against CMV and scores for cognitive function.

Original languageEnglish (US)
JournalNeuroscience Research
DOIs
StateAccepted/In press - Jul 28 2016

Keywords

  • Antibody level
  • Bipolar disorder
  • Inflammation
  • Neurocognition
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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