Infection and inflammation in schizophrenia and bipolar disorder

Teppei Tanaka, Taro Matsuda, Lindsay N. Hayes, Shuojia Yang, Katrina Rodriguez, Emily G. Severance, Robert H. Yolken, Akira Sawa, William W. Eaton

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in soluble CD14, and in BP an increase in C-reactive protein, IgM class antibodies against cytomegalovirus (CMV), and IgG class antibodies against herpes simplex virus 2. Furthermore in BP, we observed a negative relationship between IgG antibodies against CMV and scores for cognitive function.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalNeuroscience Research
StatePublished - Feb 2017


  • Antibody level
  • Bipolar disorder
  • Inflammation
  • Neurocognition
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)


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