Infantile Spasms—Have We Made Progress?

Sarah Aminoff Kelley, Kelly G. Knupp

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of the Review: The care of children with infantile spasms is full of areas of ambiguity, despite practice parameters and randomized trials. This review is to update the current care of children with infantile spasms. Recent Findings: Several recent studies have generated new data to guide management including a randomized trial supporting combination therapy of hormone treatment and vigabatrin as an initial treatment for infantile spasms. Studies have suggested that we are not consistent in our recognition of hypsarrhythmia, while additional studies suggest that the presence or absence of this pattern may not have any predictive value. Additionally, the use of appropriate medications as well as an early diagnosis has the most impact on short-term outcomes. Summary: Children with infantile spasms benefit most from early diagnosis and early treatment with appropriate standard medications such as hormonal therapy (ACTH or prednisolone) or vigabatrin.

Original languageEnglish (US)
Article number27
JournalCurrent neurology and neuroscience reports
Volume18
Issue number5
DOIs
StatePublished - May 1 2018

Keywords

  • ACTH
  • Epileptic spasms
  • Hypsarrhythmia
  • Infantile spasms
  • Vigabatrin
  • West syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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