Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial

Alastair F. Murray, Janet A. Englund, Jane Kuypers, James M. Tielsch, Joanne Katz, Subarna K. Khatry, Steven C. Leclerq, Helen Y. Chu

Research output: Contribution to journalArticle

Abstract

In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.

Original languageEnglish (US)
Pages (from-to)956-960
Number of pages5
JournalThe Journal of infectious diseases
Volume220
Issue number6
DOIs
StatePublished - Aug 9 2019

Fingerprint

Metapneumovirus
Respiratory Syncytial Viruses
Human Influenza
Immunization
Mothers
Streptococcus pneumoniae
Respiratory Tract Diseases
Nepal
Influenza Vaccines
Vaccination
Placebos
Clinical Trials
Viruses
Infection

Keywords

  • hMPV
  • influenza
  • maternal immunization
  • pneumococcus
  • RSV
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial. / Murray, Alastair F.; Englund, Janet A.; Kuypers, Jane; Tielsch, James M.; Katz, Joanne; Khatry, Subarna K.; Leclerq, Steven C.; Chu, Helen Y.

In: The Journal of infectious diseases, Vol. 220, No. 6, 09.08.2019, p. 956-960.

Research output: Contribution to journalArticle

Murray, Alastair F. ; Englund, Janet A. ; Kuypers, Jane ; Tielsch, James M. ; Katz, Joanne ; Khatry, Subarna K. ; Leclerq, Steven C. ; Chu, Helen Y. / Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial. In: The Journal of infectious diseases. 2019 ; Vol. 220, No. 6. pp. 956-960.
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