Infant Pneumococcal Carriage during Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial

Alastair F. Murray, Janet A. Englund, Jane Kuypers, James M. Tielsch, Joanne Katz, Subarna K. Khatry, Steven C. Leclerq, Helen Y. Chu

Research output: Contribution to journalArticlepeer-review

Abstract

In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection.

Original languageEnglish (US)
Pages (from-to)956-960
Number of pages5
JournalJournal of Infectious Diseases
Volume220
Issue number6
DOIs
StatePublished - Aug 9 2019

Keywords

  • RSV
  • hMPV
  • influenza
  • maternal immunization
  • pneumococcus
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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