Abstract
In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection.
Original language | English (US) |
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Pages (from-to) | 956-960 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 220 |
Issue number | 6 |
DOIs | |
State | Published - Aug 9 2019 |
Keywords
- RSV
- hMPV
- influenza
- maternal immunization
- pneumococcus
- vaccine
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases