Infant neurodevelopment following fetal growth restriction: Relationship with antepartum surveillance parameters

Ahmet Baschat, R. M. Viscardi, B. Hussey-Gardner, N. Hashmi, C. Harman

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the relationship between fetal Doppler parameters, biophysical profile score (BPP) and neurodevelopmental delay at 2 years of corrected age in infants who had been growth-restricted in utero. Methods: This was a prospective observational study including 113 pregnancies complicated by intrauterine growth restriction (IUGR) (abdominal circumference th percentile and elevated umbilical artery (UA) pulsatility index). The relationships of UA, middle cerebral artery and ductus venosus (DV) Doppler features, BPP, birth acidemia (artery pH 12), gestational age at delivery, birth weight and neonatal morbidity (i.e. bronchopulmonary dysplasia, > Grade 2 intraventricular hemorrhage, or necrotizing enterocolitis) with a 2-year neurodevelopmental delay were evaluated. Best Beginnings Developmental Screen, Bayley Scale of Infant Development II (BSID) and Clinical Adaptive/ Clinical Linguistic Auditory Milestone Stage were used. BSID 2 = 0.52, P <0.0001; 92% sensitivity and 83% specificity for delivery at 2 = 0.31, P = 0.006) and birth weight with neurodevelopmental delay (r2 = 0.54, P <0.0001; 82% sensitivity and 64% specificity for BW

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalUltrasound in Obstetrics and Gynecology
Volume33
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

Fingerprint

Umbilical Arteries
Fetal Development
Child Development
Birth Weight
Sensitivity and Specificity
Bronchopulmonary Dysplasia
Necrotizing Enterocolitis
Middle Cerebral Artery
Linguistics
Growth
Gestational Age
Observational Studies
Arteries
Parturition
Prospective Studies
Hemorrhage
Morbidity
Pregnancy

Keywords

  • Biophysical profile score
  • Ductus venosus
  • Fetal Doppler
  • Growth restriction
  • Neurodevelopment

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine

Cite this

Infant neurodevelopment following fetal growth restriction : Relationship with antepartum surveillance parameters. / Baschat, Ahmet; Viscardi, R. M.; Hussey-Gardner, B.; Hashmi, N.; Harman, C.

In: Ultrasound in Obstetrics and Gynecology, Vol. 33, No. 1, 01.2009, p. 44-50.

Research output: Contribution to journalArticle

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