Abstract
This study examined the neurobehavioral functioning of neonates prenatally exposed to methadone (n 11) or buprenorphine (n 10), who underwent the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) examinations on days 3, 5, 7, 10, and 14 post-delivery. Linear mixed model analyses revealed that NNNS scores of arousal and excitability showed significant differences between medications over time. Compared to neonates who did not require medication to treat neonatal abstinence syndrome (NAS), neonates receiving pharmacotherapy for NAS showed differences over time in quality of movement, excitability, and lethargy. Results suggest the NNNS may detect subtle differences over time between both neonates prenatally exposed to methadone or buprenorphine and neonates pharmacologically treated or untreated for NAS.
Original language | English (US) |
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Pages (from-to) | 2244-2257 |
Number of pages | 14 |
Journal | Substance Use and Misuse |
Volume | 45 |
Issue number | 13 |
DOIs | |
State | Published - Jul 2010 |
Keywords
- Pregnancy
- buprenorphine
- developmental neurobehavior
- methadone
- neonatal abstinence syndrome
- substance abuse
ASJC Scopus subject areas
- Health(social science)
- Medicine (miscellaneous)
- Public Health, Environmental and Occupational Health
- Psychiatry and Mental health