Infant neurobehavior following prenatal exposure to methadone or buprenorphine: Results from the neonatal intensive care unit network neurobehavioral scale

Hendrée E. Jones, Kevin E. O'Grady, Rolley E. Johnson, Martha Velez, Lauren M Jansson

Research output: Contribution to journalArticle

Abstract

This study examined the neurobehavioral functioning of neonates prenatally exposed to methadone (n 11) or buprenorphine (n 10), who underwent the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) examinations on days 3, 5, 7, 10, and 14 post-delivery. Linear mixed model analyses revealed that NNNS scores of arousal and excitability showed significant differences between medications over time. Compared to neonates who did not require medication to treat neonatal abstinence syndrome (NAS), neonates receiving pharmacotherapy for NAS showed differences over time in quality of movement, excitability, and lethargy. Results suggest the NNNS may detect subtle differences over time between both neonates prenatally exposed to methadone or buprenorphine and neonates pharmacologically treated or untreated for NAS.

Original languageEnglish (US)
Pages (from-to)2244-2257
Number of pages14
JournalSubstance Use and Misuse
Volume45
Issue number13
DOIs
StatePublished - Jul 2010

Fingerprint

Buprenorphine
Neonatal Intensive Care Units
Methadone
Neonatal Abstinence Syndrome
infant
Newborn Infant
medication
Lethargy
Arousal
examination
Linear Models
time
Drug Therapy

Keywords

  • buprenorphine
  • developmental neurobehavior
  • methadone
  • neonatal abstinence syndrome
  • Pregnancy
  • substance abuse

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

Infant neurobehavior following prenatal exposure to methadone or buprenorphine : Results from the neonatal intensive care unit network neurobehavioral scale. / Jones, Hendrée E.; O'Grady, Kevin E.; Johnson, Rolley E.; Velez, Martha; Jansson, Lauren M.

In: Substance Use and Misuse, Vol. 45, No. 13, 07.2010, p. 2244-2257.

Research output: Contribution to journalArticle

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