TY - JOUR
T1 - Infant immunization with pneumococcal CRM197 vaccines
T2 - Effect of saccharide size on immunogenicity and interactions with simultaneously administered vaccines
AU - Daum, Robert S.
AU - Hogerman, Deborah
AU - Rennels, Margaret B.
AU - Bewley, Kathleen
AU - Malinoski, Frank
AU - Rothstein, Edward
AU - Reisinger, Keith
AU - Block, Stan
AU - Keyserling, Harry
AU - Steinhoff, Mark
PY - 1997
Y1 - 1997
N2 - Six pentavalent pneumococcal conjugate vaccines (Pn-CRM197) were evaluated among 400 infants. The vaccines differed in saccharide chain length (oligosaccharide [OS] or polysaccharide [PS]) and saccharide quantity (0.5, 2, or 5 μg). Subjects were randomized into groups 1-6 (Pn-CRM197 recipients) or 7 (controls) for immunization at 2, 4, and 6 months of age. Pn-CRM197 were well tolerated and elicited mean antibody concentrations that exceeded those in controls for all 5 capsular serotypes. PS formulations were generally more immunogenic than their OS counterparts. For PS vaccines, a dose-response was documented (5 μg > 2 μg > 0.5 μg), but the differences between the 5- and 2-μg formulations were insignificant. The mean anti-PRP antibody concentration was significantly higher among Pn-CRM197 recipients. It is concluded that PS vaccines are more immunogenic than OS vaccines. The improved immunogenicity from Haemophilus type b oligosaccharide conjugate (HbOC) vaccine when given with Pn-CRM197 suggests that a decreased dose of HbOC vaccine may be sufficient to elicit protection.
AB - Six pentavalent pneumococcal conjugate vaccines (Pn-CRM197) were evaluated among 400 infants. The vaccines differed in saccharide chain length (oligosaccharide [OS] or polysaccharide [PS]) and saccharide quantity (0.5, 2, or 5 μg). Subjects were randomized into groups 1-6 (Pn-CRM197 recipients) or 7 (controls) for immunization at 2, 4, and 6 months of age. Pn-CRM197 were well tolerated and elicited mean antibody concentrations that exceeded those in controls for all 5 capsular serotypes. PS formulations were generally more immunogenic than their OS counterparts. For PS vaccines, a dose-response was documented (5 μg > 2 μg > 0.5 μg), but the differences between the 5- and 2-μg formulations were insignificant. The mean anti-PRP antibody concentration was significantly higher among Pn-CRM197 recipients. It is concluded that PS vaccines are more immunogenic than OS vaccines. The improved immunogenicity from Haemophilus type b oligosaccharide conjugate (HbOC) vaccine when given with Pn-CRM197 suggests that a decreased dose of HbOC vaccine may be sufficient to elicit protection.
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U2 - 10.1086/514063
DO - 10.1086/514063
M3 - Article
C2 - 9237711
AN - SCOPUS:16944366702
SN - 0022-1899
VL - 176
SP - 445
EP - 455
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -