Infant immunization with pneumococcal CRM197 vaccines: Effect of saccharide size on immunogenicity and interactions with simultaneously administered vaccines

Robert S. Daum, Deborah Hogerman, Margaret B. Rennels, Kathleen Bewley, Frank Malinoski, Edward Rothstein, Keith Reisinger, Stan Block, Harry Keyserling, Mark Steinhoff

Research output: Contribution to journalArticle

Abstract

Six pentavalent pneumococcal conjugate vaccines (Pn-CRM197) were evaluated among 400 infants. The vaccines differed in saccharide chain length (oligosaccharide [OS] or polysaccharide [PS]) and saccharide quantity (0.5, 2, or 5 μg). Subjects were randomized into groups 1-6 (Pn-CRM197 recipients) or 7 (controls) for immunization at 2, 4, and 6 months of age. Pn-CRM197 were well tolerated and elicited mean antibody concentrations that exceeded those in controls for all 5 capsular serotypes. PS formulations were generally more immunogenic than their OS counterparts. For PS vaccines, a dose-response was documented (5 μg > 2 μg > 0.5 μg), but the differences between the 5- and 2-μg formulations were insignificant. The mean anti-PRP antibody concentration was significantly higher among Pn-CRM197 recipients. It is concluded that PS vaccines are more immunogenic than OS vaccines. The improved immunogenicity from Haemophilus type b oligosaccharide conjugate (HbOC) vaccine when given with Pn-CRM197 suggests that a decreased dose of HbOC vaccine may be sufficient to elicit protection.

Original languageEnglish (US)
Pages (from-to)445-455
Number of pages11
JournalJournal of Infectious Diseases
Volume176
Issue number2
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Daum, R. S., Hogerman, D., Rennels, M. B., Bewley, K., Malinoski, F., Rothstein, E., Reisinger, K., Block, S., Keyserling, H., & Steinhoff, M. (1997). Infant immunization with pneumococcal CRM197 vaccines: Effect of saccharide size on immunogenicity and interactions with simultaneously administered vaccines. Journal of Infectious Diseases, 176(2), 445-455. https://doi.org/10.1086/514063