Industrial exposure to organophosphorus compounds: Studies of a group of workers with a decrease in esterase-staining monocytes

Edward A. Emmett, Philip G. Lewis, Fujiho Tanaka, Margit Bleecker, Robin Fox, A. Clarke Darlington, Daniel R. Synkowski, Arthur M. Dannenberg, William J. Taylor, Marshal S. Levine

Research output: Contribution to journalArticle

Abstract

When an automated counting instrument using an esterase stain was employed, decreased monocyte counts were observed in a group of process workers exposed to organophosphate esters. Their monocyte counts were not found to be depressed with manual counting or with an automated counter using another staining method. The apparent depression was transient. In these workers and a comparison group, theoretical adverse consequences of decreased monocyte esterase and also possible changes in other esterases were explored. No anergy was seen with mumps or staphylococcal phage lysate hypersensitivity skin tests. Histology of the mumps reaction was similar in both groups. The depressed monocyte counts were significantly associated with a mild reduction in erythrocyte cell acetylcholinesterase, but no reduction was seen in plasma pseudocholinesterase or lymphocyte neurotoxic esterase.

Original languageEnglish (US)
Pages (from-to)905-914
Number of pages10
JournalJournal of Occupational Medicine
Volume27
Issue number12
StatePublished - 1985

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Organophosphorus Compounds
Esterases
Monocytes
Staining and Labeling
Mumps
Staphylococcus Phages
Pseudocholinesterase
Group Processes
Organophosphates
Acetylcholinesterase
Skin Tests
Histology
Hypersensitivity
Esters
Coloring Agents
Erythrocytes
Lymphocytes
Depression

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Emmett, E. A., Lewis, P. G., Tanaka, F., Bleecker, M., Fox, R., Darlington, A. C., ... Levine, M. S. (1985). Industrial exposure to organophosphorus compounds: Studies of a group of workers with a decrease in esterase-staining monocytes. Journal of Occupational Medicine, 27(12), 905-914.

Industrial exposure to organophosphorus compounds : Studies of a group of workers with a decrease in esterase-staining monocytes. / Emmett, Edward A.; Lewis, Philip G.; Tanaka, Fujiho; Bleecker, Margit; Fox, Robin; Darlington, A. Clarke; Synkowski, Daniel R.; Dannenberg, Arthur M.; Taylor, William J.; Levine, Marshal S.

In: Journal of Occupational Medicine, Vol. 27, No. 12, 1985, p. 905-914.

Research output: Contribution to journalArticle

Emmett, EA, Lewis, PG, Tanaka, F, Bleecker, M, Fox, R, Darlington, AC, Synkowski, DR, Dannenberg, AM, Taylor, WJ & Levine, MS 1985, 'Industrial exposure to organophosphorus compounds: Studies of a group of workers with a decrease in esterase-staining monocytes', Journal of Occupational Medicine, vol. 27, no. 12, pp. 905-914.
Emmett, Edward A. ; Lewis, Philip G. ; Tanaka, Fujiho ; Bleecker, Margit ; Fox, Robin ; Darlington, A. Clarke ; Synkowski, Daniel R. ; Dannenberg, Arthur M. ; Taylor, William J. ; Levine, Marshal S. / Industrial exposure to organophosphorus compounds : Studies of a group of workers with a decrease in esterase-staining monocytes. In: Journal of Occupational Medicine. 1985 ; Vol. 27, No. 12. pp. 905-914.
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