Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

E. B. Dashinimaev, I. A. Muchkaeva, R. R. Faizullin, Y. Y. Yegorov, S. S. Akimov, V. V. Terskikh, A. V. Vasiliev, M. P. Kirpichnikov

Research output: Contribution to journalArticlepeer-review

Abstract

Reprogramming of human cells is a perspective direction of development of Cell Biology with the distant prospect of using these methods for cellular-replacing therapy in clinical practice. One of the problems rising in this regard is low reprogramming efficiency and application of undesirable oncogenes in initial techniques. In this research, we had offered the alternative modified method of reprogramming human skin fibroblasts. It has been shown that the telomerase induction increases an exit of reprogrammed cells and allows excluding oncogene c-Myc from a used set of genes.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalMoscow University Biological Sciences Bulletin
Volume67
Issue number1
DOIs
StatePublished - Aug 6 2012
Externally publishedYes

Keywords

  • human skin fibroblasts
  • reprogramming
  • telomerase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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