Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

E. B. Dashinimaev, I. A. Muchkaeva, R. R. Faizullin, Y. Y. Yegorov, Sergey Akimov, V. V. Terskikh, A. V. Vasiliev, M. P. Kirpichnikov

Research output: Contribution to journalArticle

Abstract

Reprogramming of human cells is a perspective direction of development of Cell Biology with the distant prospect of using these methods for cellular-replacing therapy in clinical practice. One of the problems rising in this regard is low reprogramming efficiency and application of undesirable oncogenes in initial techniques. In this research, we had offered the alternative modified method of reprogramming human skin fibroblasts. It has been shown that the telomerase induction increases an exit of reprogrammed cells and allows excluding oncogene c-Myc from a used set of genes.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalMoscow University Biological Sciences Bulletin
Volume67
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Cytology
telomerase
Telomerase
Fibroblasts
fibroblasts
Skin
Genes
oncogenes
Cells
myc Genes
Oncogenes
Cell Biology
skin
skin (animal)
cell biology
gene
methodology
Research
cells
therapeutics

Keywords

  • human skin fibroblasts
  • reprogramming
  • telomerase

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Dashinimaev, E. B., Muchkaeva, I. A., Faizullin, R. R., Yegorov, Y. Y., Akimov, S., Terskikh, V. V., ... Kirpichnikov, M. P. (2012). Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts. Moscow University Biological Sciences Bulletin, 67(1), 6-12. https://doi.org/10.3103/S0096392512010038

Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts. / Dashinimaev, E. B.; Muchkaeva, I. A.; Faizullin, R. R.; Yegorov, Y. Y.; Akimov, Sergey; Terskikh, V. V.; Vasiliev, A. V.; Kirpichnikov, M. P.

In: Moscow University Biological Sciences Bulletin, Vol. 67, No. 1, 2012, p. 6-12.

Research output: Contribution to journalArticle

Dashinimaev, EB, Muchkaeva, IA, Faizullin, RR, Yegorov, YY, Akimov, S, Terskikh, VV, Vasiliev, AV & Kirpichnikov, MP 2012, 'Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts', Moscow University Biological Sciences Bulletin, vol. 67, no. 1, pp. 6-12. https://doi.org/10.3103/S0096392512010038
Dashinimaev, E. B. ; Muchkaeva, I. A. ; Faizullin, R. R. ; Yegorov, Y. Y. ; Akimov, Sergey ; Terskikh, V. V. ; Vasiliev, A. V. ; Kirpichnikov, M. P. / Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts. In: Moscow University Biological Sciences Bulletin. 2012 ; Vol. 67, No. 1. pp. 6-12.
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