Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

E. B. Dashinimaev; I. A. Muchkaeva; R. R. Faizullin; Y. Y. Yegorov; S. S. Akimov; V. V. Terskikh; A. V. Vasiliev; M. P. Kirpichnikov

doi:10.3103/S0096392512010038

Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

E. B. Dashinimaev, I. A. Muchkaeva, R. R. Faizullin, Y. Y. Yegorov, S. S. Akimov, V. V. Terskikh, A. V. Vasiliev, M. P. Kirpichnikov

Research output: Contribution to journal › Article › peer-review

Abstract

Reprogramming of human cells is a perspective direction of development of Cell Biology with the distant prospect of using these methods for cellular-replacing therapy in clinical practice. One of the problems rising in this regard is low reprogramming efficiency and application of undesirable oncogenes in initial techniques. In this research, we had offered the alternative modified method of reprogramming human skin fibroblasts. It has been shown that the telomerase induction increases an exit of reprogrammed cells and allows excluding oncogene c-Myc from a used set of genes.

Original language	English (US)
Pages (from-to)	6-12
Number of pages	7
Journal	Moscow University Biological Sciences Bulletin
Volume	67
Issue number	1
DOIs	https://doi.org/10.3103/S0096392512010038
State	Published - 2012
Externally published	Yes

Keywords

human skin fibroblasts
reprogramming
telomerase

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Environmental Science(all)
Agricultural and Biological Sciences(all)

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10.3103/S0096392512010038

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Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts. / Dashinimaev, E. B.; Muchkaeva, I. A.; Faizullin, R. R.; Yegorov, Y. Y.; Akimov, S. S.; Terskikh, V. V.; Vasiliev, A. V.; Kirpichnikov, M. P.

In: Moscow University Biological Sciences Bulletin, Vol. 67, No. 1, 2012, p. 6-12.

Research output: Contribution to journal › Article › peer-review

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AU - Dashinimaev, E. B.

AU - Muchkaeva, I. A.

AU - Faizullin, R. R.

AU - Yegorov, Y. Y.

AU - Akimov, S. S.

AU - Terskikh, V. V.

AU - Vasiliev, A. V.

AU - Kirpichnikov, M. P.

N1 - Funding Information: The study was supported by FSPSTP “Studies and Projects on Priority Directions of Science and Technol ogy Development for 2007–2012” (government contract no. 16.512.11.2106, code 2011 1.2 512 050 068). Copyright: Copyright 2013 Elsevier B.V., All rights reserved.

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N2 - Reprogramming of human cells is a perspective direction of development of Cell Biology with the distant prospect of using these methods for cellular-replacing therapy in clinical practice. One of the problems rising in this regard is low reprogramming efficiency and application of undesirable oncogenes in initial techniques. In this research, we had offered the alternative modified method of reprogramming human skin fibroblasts. It has been shown that the telomerase induction increases an exit of reprogrammed cells and allows excluding oncogene c-Myc from a used set of genes.

AB - Reprogramming of human cells is a perspective direction of development of Cell Biology with the distant prospect of using these methods for cellular-replacing therapy in clinical practice. One of the problems rising in this regard is low reprogramming efficiency and application of undesirable oncogenes in initial techniques. In this research, we had offered the alternative modified method of reprogramming human skin fibroblasts. It has been shown that the telomerase induction increases an exit of reprogrammed cells and allows excluding oncogene c-Myc from a used set of genes.

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Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

Abstract

Keywords

ASJC Scopus subject areas

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