Induction of suppressor cells specific for AChR in experimental autoimmune myasthenia gravis

Kevin R. McIntosh, Daniel B Drachman

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Abstract

Suppressor cells specific (or acetylcholine receptor (AChR) were induced in a population of lymphocytes previously sensitized, to AChR, obtained from rats with experimental autoimmune myasthenia gravis (EAMG). The lymphocytes were cultured with the immunosuppressive drug cyclosporin A plus purified AChR for 7 days. These cells, when mixed with lymphocytes from rats with EAMG in vitro, strongly suppressed the antibody response to AChR. They did not inhibit antibody responses to an unrelated antigen, an indication that suppression was specific for AChR. This approach should be a useful way to induce specific suppressor cells from sensitized populations of lymphocytes and may be applicable in the treatment of autoimmune diseases such as myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)401-403
Number of pages3
JournalScience
Volume232
Issue number4748
Publication statusPublished - 1986

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