Induction of subacute murine measles encephalitis by monoclonal antibody to virus haemagglutinin

Kotti W. Rammohan, Henry F. McFarland, Dale E. McFarlin

Research output: Contribution to journalArticle

Abstract

Although the events which predispose a host to measles virus persistence remain largely unknown, measles antibody has been shown to contribute to the production of a persistent infection by this virus both in vivo and in vitro. Thus, the addition of measles antibody to cells infected with measles virus promotes virus persistence1,2. Latent measles infection occurs in newborn hamsters with maternally acquired antibody after inoculation with measles virus in the immediate neonatal period3. A subacute encephalitis with measles virus persistence has been induced in weanling BALB/c mice that received antibody after virus inoculation4 and in measles-immune primates infected with a virus derived from a patient with subacute sclerosing panencephalitis5. Measles virus consists of six polypeptides, and treatment of measles-infected cells with antibody has been shown6 to alter the pattern of their synthesis. As the antigenic specificity of the antibody responsible for these observations is not known, we decided to investigate the effects of monoclonal antibodies directed against the individual measles polypeptides. We report here that a monoclonal antibody directed against the virus haemagglutinin, unlike an antibody to the virus nucleocapsid protein, is able to induce a subacute encephalitis in vivo.

Original languageEnglish (US)
Pages (from-to)588-590
Number of pages3
JournalNature
Volume290
Issue number5807
DOIs
StatePublished - 1981
Externally publishedYes

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