Abstract
After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1496-1500 |
| Number of pages | 5 |
| Journal | Journal of the American Society of Nephrology |
| Volume | 3 |
| Issue number | 8 |
| State | Published - Feb 1993 |
| Externally published | Yes |
Keywords
- GFR
- Glomerulosclerosis
- Ketoconazole
- RBF
ASJC Scopus subject areas
- Nephrology
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Takahashi, K., Harris, R. C., Capdevila, J. H., Karara, A., Makita, K., Jacobson, H. R., Munger, K. A., & Badr, K. F. (1993). Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration. Journal of the American Society of Nephrology, 3(8), 1496-1500.