Abstract
After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1496-1500 |
| Number of pages | 5 |
| Journal | Journal of the American Society of Nephrology |
| Volume | 3 |
| Issue number | 8 |
| State | Published - Feb 1993 |
| Externally published | Yes |
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Keywords
- GFR
- Glomerulosclerosis
- Ketoconazole
- RBF
ASJC Scopus subject areas
- Nephrology
Cite this
Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy : Counterregulation of hyperfiltration. / Takahashi, Kihito; Harris, Raymond C.; Capdevila, Jorge H.; Karara, Armando; Makita, Keiko; Jacobson, Harry R.; Munger, Karen A.; Badr, Kamal F.
In: Journal of the American Society of Nephrology, Vol. 3, No. 8, 02.1993, p. 1496-1500.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy
T2 - Counterregulation of hyperfiltration
AU - Takahashi, Kihito
AU - Harris, Raymond C.
AU - Capdevila, Jorge H.
AU - Karara, Armando
AU - Makita, Keiko
AU - Jacobson, Harry R.
AU - Munger, Karen A.
AU - Badr, Kamal F.
PY - 1993/2
Y1 - 1993/2
N2 - After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P
AB - After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P
KW - GFR
KW - Glomerulosclerosis
KW - Ketoconazole
KW - RBF
UR - http://www.scopus.com/inward/record.url?scp=0027547460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027547460&partnerID=8YFLogxK
M3 - Article
C2 - 8387830
AN - SCOPUS:0027547460
VL - 3
SP - 1496
EP - 1500
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
SN - 1046-6673
IS - 8
ER -