Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration

Kihito Takahashi, Raymond C. Harris, Jorge H. Capdevila, Armando Karara, Keiko Makita, Harry R. Jacobson, Karen A. Munger, Kamal F. Badr

Research output: Contribution to journalArticlepeer-review

Abstract

After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P

Original languageEnglish (US)
Pages (from-to)1496-1500
Number of pages5
JournalJournal of the American Society of Nephrology
Volume3
Issue number8
StatePublished - Feb 1993
Externally publishedYes

Keywords

  • GFR
  • Glomerulosclerosis
  • Ketoconazole
  • RBF

ASJC Scopus subject areas

  • Nephrology

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