Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration

Kihito Takahashi; Raymond C. Harris; Jorge H. Capdevila; Armando Karara; Keiko Makita; Harry R. Jacobson; Karen A. Munger; Kamal F. Badr

Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration

Kihito Takahashi, Raymond C. Harris, Jorge H. Capdevila, Armando Karara, Keiko Makita, Harry R. Jacobson, Karen A. Munger, Kamal F. Badr

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P

Original language	English (US)
Pages (from-to)	1496-1500
Number of pages	5
Journal	Journal of the American Society of Nephrology
Volume	3
Issue number	8
State	Published - Feb 1993
Externally published	Yes

Keywords

GFR
Glomerulosclerosis
Ketoconazole
RBF

ASJC Scopus subject areas

Nephrology

Cite this

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title = "Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration",

abstract = "After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P",

keywords = "GFR, Glomerulosclerosis, Ketoconazole, RBF",

author = "Kihito Takahashi and Harris, {Raymond C.} and Capdevila, {Jorge H.} and Armando Karara and Keiko Makita and Jacobson, {Harry R.} and Munger, {Karen A.} and Badr, {Kamal F.}",

year = "1993",

month = feb,

language = "English (US)",

volume = "3",

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T1 - Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy

T2 - Counterregulation of hyperfiltration

AU - Takahashi, Kihito

AU - Harris, Raymond C.

AU - Capdevila, Jorge H.

AU - Karara, Armando

AU - Makita, Keiko

AU - Jacobson, Harry R.

AU - Munger, Karen A.

AU - Badr, Kamal F.

PY - 1993/2

Y1 - 1993/2

N2 - After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P

AB - After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P

KW - GFR

KW - Glomerulosclerosis

KW - Ketoconazole

KW - RBF

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M3 - Article

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AN - SCOPUS:0027547460

VL - 3

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JF - Journal of the American Society of Nephrology : JASN

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ER -

Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration

Abstract

Keywords

ASJC Scopus subject areas

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