Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration

Kihito Takahashi, Raymond C. Harris, Jorge H. Capdevila, Armando Karara, Keiko Makita, Harry R. Jacobson, Karen A. Munger, Kamal F. Badr

Research output: Contribution to journalArticle

Abstract

After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P

Original languageEnglish (US)
Pages (from-to)1496-1500
Number of pages5
JournalJournal of the American Society of Nephrology
Volume3
Issue number8
StatePublished - Feb 1993
Externally publishedYes

Fingerprint

Cytochrome P-450 Enzyme System
Kidney
Ketoconazole
Nephrectomy
Cytochrome P-450 Enzyme Inhibitors

Keywords

  • GFR
  • Glomerulosclerosis
  • Ketoconazole
  • RBF

ASJC Scopus subject areas

  • Nephrology

Cite this

Takahashi, K., Harris, R. C., Capdevila, J. H., Karara, A., Makita, K., Jacobson, H. R., ... Badr, K. F. (1993). Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration. Journal of the American Society of Nephrology, 3(8), 1496-1500.

Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy : Counterregulation of hyperfiltration. / Takahashi, Kihito; Harris, Raymond C.; Capdevila, Jorge H.; Karara, Armando; Makita, Keiko; Jacobson, Harry R.; Munger, Karen A.; Badr, Kamal F.

In: Journal of the American Society of Nephrology, Vol. 3, No. 8, 02.1993, p. 1496-1500.

Research output: Contribution to journalArticle

Takahashi, K, Harris, RC, Capdevila, JH, Karara, A, Makita, K, Jacobson, HR, Munger, KA & Badr, KF 1993, 'Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration', Journal of the American Society of Nephrology, vol. 3, no. 8, pp. 1496-1500.
Takahashi, Kihito ; Harris, Raymond C. ; Capdevila, Jorge H. ; Karara, Armando ; Makita, Keiko ; Jacobson, Harry R. ; Munger, Karen A. ; Badr, Kamal F. / Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy : Counterregulation of hyperfiltration. In: Journal of the American Society of Nephrology. 1993 ; Vol. 3, No. 8. pp. 1496-1500.
@article{c28be28533ca458c819264d818f0c429,
title = "Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: Counterregulation of hyperfiltration",
abstract = "After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200{\%} at 1 wk and 285{\%} at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75{\%} inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P",
keywords = "GFR, Glomerulosclerosis, Ketoconazole, RBF",
author = "Kihito Takahashi and Harris, {Raymond C.} and Capdevila, {Jorge H.} and Armando Karara and Keiko Makita and Jacobson, {Harry R.} and Munger, {Karen A.} and Badr, {Kamal F.}",
year = "1993",
month = "2",
language = "English (US)",
volume = "3",
pages = "1496--1500",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "8",

}

TY - JOUR

T1 - Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy

T2 - Counterregulation of hyperfiltration

AU - Takahashi, Kihito

AU - Harris, Raymond C.

AU - Capdevila, Jorge H.

AU - Karara, Armando

AU - Makita, Keiko

AU - Jacobson, Harry R.

AU - Munger, Karen A.

AU - Badr, Kamal F.

PY - 1993/2

Y1 - 1993/2

N2 - After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P

AB - After unilateral nephrectomy (UNx) in the rat, cytochrome P-450 (cP-450)-linked arachidonate enzymatic activity was markedly and specifically induced in microsomal fractions from the remaining kidney. The enzymatic activity reached 200% at 1 wk and 285% at 2 wk post-UNx as compared with non-UNx controls. Mean baseline values for GFR and RPF rate in the remaining kidney 2 wk after UNx were 1.56 ± 0.10 and 6.47 ± 0.35 mL/min, respectively. In these rats, the administration of ketoconazole, a cP-450 inhibitor, led to 75% inhibition of renal cP-450 arachidonate metabolism and was associated with acute augmentations in both GFR and RPF to 1.82 ± 0.18 (P

KW - GFR

KW - Glomerulosclerosis

KW - Ketoconazole

KW - RBF

UR - http://www.scopus.com/inward/record.url?scp=0027547460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027547460&partnerID=8YFLogxK

M3 - Article

C2 - 8387830

AN - SCOPUS:0027547460

VL - 3

SP - 1496

EP - 1500

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 8

ER -