Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue

D. E. McCloskey, Robert A Casero, P. M. Woster, N. E. Davidson

Research output: Contribution to journalArticle

Abstract

The need for antineoplastic compounds with navel mechanisms of action is great. One such agent is the recently synthesized polyamine analogue N1- ethyl-N11-((cyclopropyllmethyl)-4,8-diazaundecanc (CPENSpm). Exposure of hormone-dependent and -independent human breast cancer cells to 0.1-10 μM CPENSpm led to both growth inhibition and induction of programmed cell death. Fragmentation of DNA to high molecular weight fragments and oligonucleosomal- sized fragments, both characteristic of programmed cell death, was determined to be time and concentration dependent. Depletion of natural polyamine pools and accumulation of the analogue was also demonstrated. These data provide the first evidence that a polyamine analogue induces programmed cell death.

Original languageEnglish (US)
Pages (from-to)3233-3236
Number of pages4
JournalCancer Research
Volume55
Issue number15
StatePublished - 1995

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Polyamines
Cell Death
Breast Neoplasms
DNA Fragmentation
Antineoplastic Agents
Molecular Weight
Hormones
Growth
N(1)-ethyl-N-(11)-((cyclopropyl)methyl)-4,8-diazaundecane-1,11-diamine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. / McCloskey, D. E.; Casero, Robert A; Woster, P. M.; Davidson, N. E.

In: Cancer Research, Vol. 55, No. 15, 1995, p. 3233-3236.

Research output: Contribution to journalArticle

McCloskey, D. E. ; Casero, Robert A ; Woster, P. M. ; Davidson, N. E. / Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. In: Cancer Research. 1995 ; Vol. 55, No. 15. pp. 3233-3236.
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